Volatile sulphur compounds in morning breath of human volunteers

Johannes Snel; Maurits Burgering; Bart Smit; Wouter Noordman; Albert Tangerman; Edwin G. Winkel; Michiel Kleerebezem

doi:10.1016/j.archoralbio.2010.08.016

Volatile sulphur compounds in morning breath of human volunteers

Johannes Snel^*, Maurits Burgering, Bart Smit, Wouter Noordman, Albert Tangerman, Edwin G. Winkel, Michiel Kleerebezem

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: Morning breath contains elevated concentrations of volatile sulphur components (VSCs). Therefore, morning breath is recognised as a surrogate target for interventions on breath quality. Nevertheless, factors influencing morning breath are poorly understood. Our aim was to evaluate concentrations of VSC at the time of awakening.

Methods: A procedure was developed to collect breath samples at home. Intra- and inter-person variations were determined in two small studies based on measurements of hydrogen sulphide, methyl mercaptan and dimethyl sulphide in healthy volunteers.

Results: Highest levels of VSC were found directly after waking up, followed by a significant decline afterward. Considerable day-to-day variation was found, but could not be linked to dietary intake. A significantly higher concentration of H2S and CH3SH was observed in the group of female subjects compared to males.

Conclusions: When morning breath is used as a target for interventions, breath collected at the time of or shortly after waking up is preferred over breath collected later during the morning. Gender plays an important role in VSC levels, and should be taken into account. (C) 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	29-34
Number of pages	6
Journal	Archives of Oral Biology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/j.archoralbio.2010.08.016
Publication status	Published - Jan-2011

Keywords

Halitosis
Morning breath
Malodor
Gender
Hydrogen sulphide
Methyl mercaptan
Dimethyl sulphide
ORAL MALODOR
HEALTHY-SUBJECTS
FLOW-RATE
HALITOSIS
GENDER
MOUTH
SULFIDE
SALIVA
WHOLE
ODOR

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title = "Volatile sulphur compounds in morning breath of human volunteers",

abstract = "Objective: Morning breath contains elevated concentrations of volatile sulphur components (VSCs). Therefore, morning breath is recognised as a surrogate target for interventions on breath quality. Nevertheless, factors influencing morning breath are poorly understood. Our aim was to evaluate concentrations of VSC at the time of awakening.Methods: A procedure was developed to collect breath samples at home. Intra- and inter-person variations were determined in two small studies based on measurements of hydrogen sulphide, methyl mercaptan and dimethyl sulphide in healthy volunteers.Results: Highest levels of VSC were found directly after waking up, followed by a significant decline afterward. Considerable day-to-day variation was found, but could not be linked to dietary intake. A significantly higher concentration of H2S and CH3SH was observed in the group of female subjects compared to males.Conclusions: When morning breath is used as a target for interventions, breath collected at the time of or shortly after waking up is preferred over breath collected later during the morning. Gender plays an important role in VSC levels, and should be taken into account. (C) 2010 Elsevier Ltd. All rights reserved.",

keywords = "Halitosis, Morning breath, Malodor, Gender, Hydrogen sulphide, Methyl mercaptan, Dimethyl sulphide, ORAL MALODOR, HEALTHY-SUBJECTS, FLOW-RATE, HALITOSIS, GENDER, MOUTH, SULFIDE, SALIVA, WHOLE, ODOR",

author = "Johannes Snel and Maurits Burgering and Bart Smit and Wouter Noordman and Albert Tangerman and Winkel, {Edwin G.} and Michiel Kleerebezem",

year = "2011",

month = jan,

doi = "10.1016/j.archoralbio.2010.08.016",

language = "English",

volume = "56",

pages = "29--34",

journal = "Archives of Oral Biology",

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AU - Snel, Johannes

AU - Burgering, Maurits

AU - Smit, Bart

AU - Noordman, Wouter

AU - Tangerman, Albert

AU - Winkel, Edwin G.

AU - Kleerebezem, Michiel

PY - 2011/1

Y1 - 2011/1

N2 - Objective: Morning breath contains elevated concentrations of volatile sulphur components (VSCs). Therefore, morning breath is recognised as a surrogate target for interventions on breath quality. Nevertheless, factors influencing morning breath are poorly understood. Our aim was to evaluate concentrations of VSC at the time of awakening.Methods: A procedure was developed to collect breath samples at home. Intra- and inter-person variations were determined in two small studies based on measurements of hydrogen sulphide, methyl mercaptan and dimethyl sulphide in healthy volunteers.Results: Highest levels of VSC were found directly after waking up, followed by a significant decline afterward. Considerable day-to-day variation was found, but could not be linked to dietary intake. A significantly higher concentration of H2S and CH3SH was observed in the group of female subjects compared to males.Conclusions: When morning breath is used as a target for interventions, breath collected at the time of or shortly after waking up is preferred over breath collected later during the morning. Gender plays an important role in VSC levels, and should be taken into account. (C) 2010 Elsevier Ltd. All rights reserved.

AB - Objective: Morning breath contains elevated concentrations of volatile sulphur components (VSCs). Therefore, morning breath is recognised as a surrogate target for interventions on breath quality. Nevertheless, factors influencing morning breath are poorly understood. Our aim was to evaluate concentrations of VSC at the time of awakening.Methods: A procedure was developed to collect breath samples at home. Intra- and inter-person variations were determined in two small studies based on measurements of hydrogen sulphide, methyl mercaptan and dimethyl sulphide in healthy volunteers.Results: Highest levels of VSC were found directly after waking up, followed by a significant decline afterward. Considerable day-to-day variation was found, but could not be linked to dietary intake. A significantly higher concentration of H2S and CH3SH was observed in the group of female subjects compared to males.Conclusions: When morning breath is used as a target for interventions, breath collected at the time of or shortly after waking up is preferred over breath collected later during the morning. Gender plays an important role in VSC levels, and should be taken into account. (C) 2010 Elsevier Ltd. All rights reserved.

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KW - Methyl mercaptan

KW - Dimethyl sulphide

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KW - FLOW-RATE

KW - HALITOSIS

KW - GENDER

KW - MOUTH

KW - SULFIDE

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KW - WHOLE

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DO - 10.1016/j.archoralbio.2010.08.016

M3 - Article

SN - 0003-9969

VL - 56

SP - 29

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JO - Archives of Oral Biology

JF - Archives of Oral Biology

IS - 1

ER -

Volatile sulphur compounds in morning breath of human volunteers

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