Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole

Angela Simeon; Ida J. van der Klei; Marten Veenhuis; Dieter H. Wolf

doi:10.1016/0014-5793(92)81254-J

Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole

Angela Simeon, Ida J. van der Klei, Marten Veenhuis, Dieter H. Wolf

Groningen Biomolecular Sciences and Biotechnology Institute

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Abstract

Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole. Mutants defective in the major vacuolar endopeptidases, proteinase yscA and yscB, lead to accumulation of ubiquitin-protein conjugates in this cellular organelle.

Original language	English
Pages (from-to)	231-235
Number of pages	5
Journal	FEBS Letters
Volume	301
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(92)81254-J
Publication status	Published - 20-Apr-1992

Keywords

PROTEOLYSIS
UBIQUITIN
VACUOLE
LYSOSOME
YEAST
SACCHAROMYCES-CEREVISIAE
CELLS
LOCALIZATION
GLYCOPROTEIN
DEGRADATION
CATALYSTS
TURNOVER
ENZYMES
GROWTH

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title = "Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole",

abstract = "Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole. Mutants defective in the major vacuolar endopeptidases, proteinase yscA and yscB, lead to accumulation of ubiquitin-protein conjugates in this cellular organelle.",

keywords = "PROTEOLYSIS, UBIQUITIN, VACUOLE, LYSOSOME, YEAST, SACCHAROMYCES-CEREVISIAE, CELLS, LOCALIZATION, GLYCOPROTEIN, DEGRADATION, CATALYSTS, TURNOVER, ENZYMES, GROWTH",

author = "Angela Simeon and Klei, {Ida J. van der} and Marten Veenhuis and Wolf, {Dieter H.}",

note = "Relation: http://www.rug.nl/gbb/ date_submitted:2007 Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute",

year = "1992",

month = apr,

day = "20",

doi = "10.1016/0014-5793(92)81254-J",

language = "English",

volume = "301",

pages = "231--235",

journal = "FEBS Letters",

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T1 - Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole

AU - Simeon, Angela

AU - Klei, Ida J. van der

AU - Veenhuis, Marten

AU - Wolf, Dieter H.

N1 - Relation: http://www.rug.nl/gbb/ date_submitted:2007 Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute

PY - 1992/4/20

Y1 - 1992/4/20

N2 - Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole. Mutants defective in the major vacuolar endopeptidases, proteinase yscA and yscB, lead to accumulation of ubiquitin-protein conjugates in this cellular organelle.

AB - Ubiquitin, an evolutionary highly conserved protein, is known to be involved in selective proteolysis in the cytoplasm. Here we show that ubiquitin-protein conjugates are also found in the yeast vacuole. Mutants defective in the major vacuolar endopeptidases, proteinase yscA and yscB, lead to accumulation of ubiquitin-protein conjugates in this cellular organelle.

KW - PROTEOLYSIS

KW - UBIQUITIN

KW - VACUOLE

KW - LYSOSOME

KW - YEAST

KW - SACCHAROMYCES-CEREVISIAE

KW - CELLS

KW - LOCALIZATION

KW - GLYCOPROTEIN

KW - DEGRADATION

KW - CATALYSTS

KW - TURNOVER

KW - ENZYMES

KW - GROWTH

U2 - 10.1016/0014-5793(92)81254-J

DO - 10.1016/0014-5793(92)81254-J

M3 - Article

VL - 301

SP - 231

EP - 235

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Ubiquitin, a central component of selective cytoplasmic proteolysis, is linked to proteins residing at the locus of non-selective proteolysis, the vacuole

Abstract

Keywords

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