Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

Anne Vrieze; Els Van Nood; Frits Holleman; Jarkko Salojarvi; Ruud S. Kootte; Joep F. W. M. Bartelsman; Geesje M. Dallinga-Thie; Mariette T. Ackermans; Mireille J. Serlie; Raish Oozeer; Muriel Derrien; Anne Druesne; Johan E.T. van Hylckama Vlieg; Vincent W. Bloks; Albert K. Groen; Hans G. H. J. Heilig; Erwin G. Zoetendal; Erik S. Stroes; Willem M. de Vos; Joost B. L. Hoekstra; Max Nieuwdorp

doi:10.1053/j.gastro.2012.06.031

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

Anne Vrieze, Els Van Nood, Frits Holleman, Jarkko Salojarvi, Ruud S. Kootte, Joep F. W. M. Bartelsman, Geesje M. Dallinga-Thie, Mariette T. Ackermans, Mireille J. Serlie, Raish Oozeer, Muriel Derrien, Anne Druesne, Johan E.T. van Hylckama Vlieg, Vincent W. Bloks, Albert K. Groen, Hans G. H. J. Heilig, Erwin G. Zoetendal, Erik S. Stroes, Willem M. de Vos, Joost B. L. HoekstraMax Nieuwdorp^*

^*Corresponding author for this work

Center for Liver, Digestive and Metabolic Diseases (CLDM)

Research output: Contribution to journal › Article › Academic › peer-review

2289 Citations (Scopus)

Abstract

Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 mu mol/kg/min; P <.05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).

Original language	English
Pages (from-to)	913-+
Number of pages	11
Journal	Gastroenterology
Volume	143
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2012.06.031
Publication status	Published - Oct-2012

Keywords

Bacteria
Clinical Trial
Diabetes
Short-Chain Fatty Acids
GUT MICROBIOME
BUTYRATE
OBESITY
RESISTANCE
BACTERIA
STORAGE
TRACT
PROBE

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Vrieze, A., Van Nood, E., Holleman, F., Salojarvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga-Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., Derrien, M., Druesne, A., van Hylckama Vlieg, J. E. T., Bloks, V. W., Groen, A. K., Heilig, H. G. H. J., Zoetendal, E. G., Stroes, E. S., de Vos, W. M., ... Nieuwdorp, M. (2012). Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome. Gastroenterology, 143(4), 913-+. https://doi.org/10.1053/j.gastro.2012.06.031

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title = "Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome",

abstract = "Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 mu mol/kg/min; P <.05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).",

keywords = "Bacteria, Clinical Trial, Diabetes, Short-Chain Fatty Acids, GUT MICROBIOME, BUTYRATE, OBESITY, RESISTANCE, BACTERIA, STORAGE, TRACT, PROBE",

author = "Anne Vrieze and {Van Nood}, Els and Frits Holleman and Jarkko Salojarvi and Kootte, {Ruud S.} and Bartelsman, {Joep F. W. M.} and Dallinga-Thie, {Geesje M.} and Ackermans, {Mariette T.} and Serlie, {Mireille J.} and Raish Oozeer and Muriel Derrien and Anne Druesne and {van Hylckama Vlieg}, {Johan E.T.} and Bloks, {Vincent W.} and Groen, {Albert K.} and Heilig, {Hans G. H. J.} and Zoetendal, {Erwin G.} and Stroes, {Erik S.} and {de Vos}, {Willem M.} and Hoekstra, {Joost B. L.} and Max Nieuwdorp",

year = "2012",

month = oct,

doi = "10.1053/j.gastro.2012.06.031",

language = "English",

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journal = "Gastroenterology",

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Vrieze, A, Van Nood, E, Holleman, F, Salojarvi, J, Kootte, RS, Bartelsman, JFWM, Dallinga-Thie, GM, Ackermans, MT, Serlie, MJ, Oozeer, R, Derrien, M, Druesne, A, van Hylckama Vlieg, JET, Bloks, VW, Groen, AK, Heilig, HGHJ, Zoetendal, EG, Stroes, ES, de Vos, WM, Hoekstra, JBL & Nieuwdorp, M 2012, 'Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome', Gastroenterology, vol. 143, no. 4, pp. 913-+. https://doi.org/10.1053/j.gastro.2012.06.031

TY - JOUR

T1 - Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

AU - Vrieze, Anne

AU - Van Nood, Els

AU - Holleman, Frits

AU - Salojarvi, Jarkko

AU - Kootte, Ruud S.

AU - Bartelsman, Joep F. W. M.

AU - Dallinga-Thie, Geesje M.

AU - Ackermans, Mariette T.

AU - Serlie, Mireille J.

AU - Oozeer, Raish

AU - Derrien, Muriel

AU - Druesne, Anne

AU - van Hylckama Vlieg, Johan E.T.

AU - Bloks, Vincent W.

AU - Groen, Albert K.

AU - Heilig, Hans G. H. J.

AU - Zoetendal, Erwin G.

AU - Stroes, Erik S.

AU - de Vos, Willem M.

AU - Hoekstra, Joost B. L.

AU - Nieuwdorp, Max

PY - 2012/10

Y1 - 2012/10

N2 - Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 mu mol/kg/min; P <.05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).

AB - Alterations in intestinal microbiota are associated with obesity and insulin resistance. We studied the effects of infusing intestinal microbiota from lean donors to male recipients with metabolic syndrome on the recipients' microbiota composition and glucose metabolism. Subjects were assigned randomly to groups that were given small intestinal infusions of allogenic or autologous microbiota. Six weeks after infusion of microbiota from lean donors, insulin sensitivity of recipients increased (median rate of glucose disappearance changed from 26.2 to 45.3 mu mol/kg/min; P <.05) along with levels of butyrate-producing intestinal microbiota. Intestinal microbiota might be developed as therapeutic agents to increase insulin sensitivity in humans; www.trialregister.nl; registered at the Dutch Trial Register (NTR1776).

KW - Bacteria

KW - Clinical Trial

KW - Diabetes

KW - Short-Chain Fatty Acids

KW - GUT MICROBIOME

KW - BUTYRATE

KW - OBESITY

KW - RESISTANCE

KW - BACTERIA

KW - STORAGE

KW - TRACT

KW - PROBE

U2 - 10.1053/j.gastro.2012.06.031

DO - 10.1053/j.gastro.2012.06.031

M3 - Article

SN - 0016-5085

VL - 143

SP - 913-+

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

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Keywords

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