Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection

Erwan Piriou; Karel van Dort; Sigrid Otto; Marinus H J van Oers; Debbie van Baarle

doi:10.1086/524079

Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection

Erwan Piriou, Karel van Dort, Sigrid Otto, Marinus H J van Oers, Debbie van Baarle^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.

Original language	English
Pages (from-to)	313-6
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	46
Issue number	2
DOIs	https://doi.org/10.1086/524079
Publication status	Published - 15-Jan-2008
Externally published	Yes

Keywords

B-Lymphocytes/immunology
DNA, Viral/genetics
Epstein-Barr Virus Infections/immunology
HIV/growth & development
HIV Infections/immunology
HIV Seropositivity/immunology
Herpesvirus 4, Human/genetics
Humans
Viral Load

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10.1086/524079

Tight Regulation of the Epstein-Barr Virus SetpointFinal publisher's version, 497 KBLicence: Taverne

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title = "Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection",

abstract = "Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.",

keywords = "B-Lymphocytes/immunology, DNA, Viral/genetics, Epstein-Barr Virus Infections/immunology, HIV/growth & development, HIV Infections/immunology, HIV Seropositivity/immunology, Herpesvirus 4, Human/genetics, Humans, Viral Load",

author = "Erwan Piriou and {van Dort}, Karel and Sigrid Otto and {van Oers}, {Marinus H J} and {van Baarle}, Debbie",

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doi = "10.1086/524079",

language = "English",

volume = "46",

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journal = "Clinical Infectious Diseases",

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T2 - interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection

AU - Piriou, Erwan

AU - van Dort, Karel

AU - Otto, Sigrid

AU - van Oers, Marinus H J

AU - van Baarle, Debbie

PY - 2008/1/15

Y1 - 2008/1/15

N2 - Healthy individuals carry a constant number of Epstein-Barr virus-infected B cells in the peripheral blood over time. Here, we show that interindividual differences in Epstein-Barr virus DNA levels are maintained after HIV infection, providing evidence for the existence of an individual Epstein-Barr virus setpoint. Immune activation may contribute to the increase in this setpoint after human immunodeficiency virus seroconversion.

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KW - B-Lymphocytes/immunology

KW - DNA, Viral/genetics

KW - Epstein-Barr Virus Infections/immunology

KW - HIV/growth & development

KW - HIV Infections/immunology

KW - HIV Seropositivity/immunology

KW - Herpesvirus 4, Human/genetics

KW - Humans

KW - Viral Load

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DO - 10.1086/524079

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 2

ER -

Tight regulation of the Epstein-Barr virus setpoint: interindividual differences in Epstein-Barr virus DNA load are conserved after HIV infection

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