TY - JOUR
T1 - The First Case of Ischemia-Free Kidney Transplantation in Humans
AU - He, Xiaoshun
AU - Chen, Guodong
AU - Zhu, Zebin
AU - Zhang, Zhiheng
AU - Yuan, Xiaopeng
AU - Han, Ming
AU - Zhao, Qiang
AU - Zheng, Yitao
AU - Tang, Yunhua
AU - Huang, Shanzhou
AU - Wang, Linhe
AU - van Leeuwen, Otto B.
AU - Wang, Xiaoping
AU - Chen, Chuanbao
AU - Mo, Liqiu
AU - Jiao, Xingyuan
AU - Li, Xianchang
AU - Wang, Changxi
AU - Huang, Jiefu
AU - Cui, Jun
AU - Guo, Zhiyong
PY - 2019/12/11
Y1 - 2019/12/11
N2 - Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.
AB - Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT). Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion. Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery. Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.
KW - kidney transplantation
KW - ischemia-reperfusion injury
KW - normothermic machine perfusion
KW - ischemia-free kidney transplantation
KW - ischemia-free organ transplantation
KW - VIVO NORMOTHERMIC PERFUSION
KW - DELAYED GRAFT FUNCTION
KW - INJURY
KW - BIOMARKERS
KW - ALLOGRAFT
KW - SURVIVAL
KW - DONORS
U2 - 10.3389/fmed.2019.00276
DO - 10.3389/fmed.2019.00276
M3 - Article
SN - 2095-0217
VL - 6
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 276
ER -