The Effects of Blood Transfusion on Delirium Incidence

Vera van der Zanden; Sara J. Beishuizen; Rikie M. Scholtens; Annemarieke de Jonghe; Sophia E. de Rooij; Barbara C. van Munster

doi:10.1016/j.jamda.2016.04.008

The Effects of Blood Transfusion on Delirium Incidence

Vera van der Zanden, Sara J. Beishuizen, Rikie M. Scholtens, Annemarieke de Jonghe, Sophia E. de Rooij, Barbara C. van Munster^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

Abstract

Background: Both anemia and blood transfusion could be precipitating factors for delirium; hence in postoperative patients with anemia at high risk for delirium, it is controversial whether transfusion is the best option. The aim of this study is to investigate the association of anemia and delirium and the role of blood transfusion within the multicomponent prevention strategy of delirium.

Methods: We conducted a substudy of a multicenter randomized controlled trial. Four hundred fifteen patients aged 65 to 102 years old admitted for hip fracture surgery were enrolled. Delirium was assessed daily using criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Data on hemoglobin values and transfusion were collected from the electronic medical records.

Results: One hundred fifteen (32.5%) patients experienced delirium during hospitalization, 238 (57.5%) had a hemoglobin level

Conclusion: Low hemoglobin level is associated with delirium, and receiving a blood transfusion is associated with a lower delirium incidence. It would be interesting to investigate the effect of blood transfusion as part of the multicomponent treatment of delirium in patients with anemia. (C) 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine.

Original language	English
Pages (from-to)	748-753
Number of pages	6
Journal	Journal of the American Medical Directors Association
Volume	17
Issue number	8
DOIs	https://doi.org/10.1016/j.jamda.2016.04.008
Publication status	Published - 1-Aug-2016

Keywords

Delirium
anemia
transfusion
elderly
hip fracture
RANDOMIZED CONTROLLED-TRIAL
HIP FRACTURE PATIENTS
INTENSIVE-CARE-UNIT
POSTOPERATIVE DELIRIUM
CARDIAC-SURGERY
RISK-FACTORS
INFORMANT QUESTIONNAIRE
INFLAMMATORY RESPONSE
COGNITIVE DECLINE
ELDERLY IQCODE

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title = "The Effects of Blood Transfusion on Delirium Incidence",

abstract = "Background: Both anemia and blood transfusion could be precipitating factors for delirium; hence in postoperative patients with anemia at high risk for delirium, it is controversial whether transfusion is the best option. The aim of this study is to investigate the association of anemia and delirium and the role of blood transfusion within the multicomponent prevention strategy of delirium.Methods: We conducted a substudy of a multicenter randomized controlled trial. Four hundred fifteen patients aged 65 to 102 years old admitted for hip fracture surgery were enrolled. Delirium was assessed daily using criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Data on hemoglobin values and transfusion were collected from the electronic medical records.Results: One hundred fifteen (32.5%) patients experienced delirium during hospitalization, 238 (57.5%) had a hemoglobin levelConclusion: Low hemoglobin level is associated with delirium, and receiving a blood transfusion is associated with a lower delirium incidence. It would be interesting to investigate the effect of blood transfusion as part of the multicomponent treatment of delirium in patients with anemia. (C) 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine.",

keywords = "Delirium, anemia, transfusion, elderly, hip fracture, RANDOMIZED CONTROLLED-TRIAL, HIP FRACTURE PATIENTS, INTENSIVE-CARE-UNIT, POSTOPERATIVE DELIRIUM, CARDIAC-SURGERY, RISK-FACTORS, INFORMANT QUESTIONNAIRE, INFLAMMATORY RESPONSE, COGNITIVE DECLINE, ELDERLY IQCODE",

author = "{van der Zanden}, Vera and Beishuizen, {Sara J.} and Scholtens, {Rikie M.} and {de Jonghe}, Annemarieke and {de Rooij}, {Sophia E.} and {van Munster}, {Barbara C.}",

year = "2016",

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doi = "10.1016/j.jamda.2016.04.008",

language = "English",

volume = "17",

pages = "748--753",

journal = "Journal of the American Medical Directors Association",

issn = "1525-8610",

publisher = "ELSEVIER SCIENCE INC",

number = "8",

}

TY - JOUR

T1 - The Effects of Blood Transfusion on Delirium Incidence

AU - van der Zanden, Vera

AU - Beishuizen, Sara J.

AU - Scholtens, Rikie M.

AU - de Jonghe, Annemarieke

AU - de Rooij, Sophia E.

AU - van Munster, Barbara C.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Background: Both anemia and blood transfusion could be precipitating factors for delirium; hence in postoperative patients with anemia at high risk for delirium, it is controversial whether transfusion is the best option. The aim of this study is to investigate the association of anemia and delirium and the role of blood transfusion within the multicomponent prevention strategy of delirium.Methods: We conducted a substudy of a multicenter randomized controlled trial. Four hundred fifteen patients aged 65 to 102 years old admitted for hip fracture surgery were enrolled. Delirium was assessed daily using criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Data on hemoglobin values and transfusion were collected from the electronic medical records.Results: One hundred fifteen (32.5%) patients experienced delirium during hospitalization, 238 (57.5%) had a hemoglobin levelConclusion: Low hemoglobin level is associated with delirium, and receiving a blood transfusion is associated with a lower delirium incidence. It would be interesting to investigate the effect of blood transfusion as part of the multicomponent treatment of delirium in patients with anemia. (C) 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine.

AB - Background: Both anemia and blood transfusion could be precipitating factors for delirium; hence in postoperative patients with anemia at high risk for delirium, it is controversial whether transfusion is the best option. The aim of this study is to investigate the association of anemia and delirium and the role of blood transfusion within the multicomponent prevention strategy of delirium.Methods: We conducted a substudy of a multicenter randomized controlled trial. Four hundred fifteen patients aged 65 to 102 years old admitted for hip fracture surgery were enrolled. Delirium was assessed daily using criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. Data on hemoglobin values and transfusion were collected from the electronic medical records.Results: One hundred fifteen (32.5%) patients experienced delirium during hospitalization, 238 (57.5%) had a hemoglobin levelConclusion: Low hemoglobin level is associated with delirium, and receiving a blood transfusion is associated with a lower delirium incidence. It would be interesting to investigate the effect of blood transfusion as part of the multicomponent treatment of delirium in patients with anemia. (C) 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine.

KW - Delirium

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KW - INTENSIVE-CARE-UNIT

KW - POSTOPERATIVE DELIRIUM

KW - CARDIAC-SURGERY

KW - RISK-FACTORS

KW - INFORMANT QUESTIONNAIRE

KW - INFLAMMATORY RESPONSE

KW - COGNITIVE DECLINE

KW - ELDERLY IQCODE

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SN - 1525-8610

VL - 17

SP - 748

EP - 753

JO - Journal of the American Medical Directors Association

JF - Journal of the American Medical Directors Association

IS - 8

ER -

The Effects of Blood Transfusion on Delirium Incidence

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