TY - CHAP
T1 - The Canonical and Accessory Sec System of Gram-positive Bacteria
AU - Prabudiansyah, Irfan
AU - Driessen, Arnold J. M.
PY - 2017
Y1 - 2017
N2 - The Sec system is present in all bacteria and responsible for the translocation of the majority of proteins across the cytoplasmic membrane. The system consists of two principal components: the ATPase motor protein, SecA, and the protein-conducting channel, SecYEG. In addition to this canonical Sec system, several Gram-positive bacteria also possess a so-called accessory Sec system. This is a specialized translocation system that is responsible for the export of a subset of secretory proteins, including virulence factors. The accessory Sec system consists of a second SecA paralog, termed SecA2, with or without a second SecY paralog, termed SecY2. In some bacteria, the accessory Sec system is dependent on the canonical Sec system for functionality, while in other bacteria, they can function independently. In this review, we provide an overview of the current knowledge of the canonical and accessory Sec system of Gram-positive bacteria with a focus on the primary component of the Sec translocase, SecA and SecYEG.
AB - The Sec system is present in all bacteria and responsible for the translocation of the majority of proteins across the cytoplasmic membrane. The system consists of two principal components: the ATPase motor protein, SecA, and the protein-conducting channel, SecYEG. In addition to this canonical Sec system, several Gram-positive bacteria also possess a so-called accessory Sec system. This is a specialized translocation system that is responsible for the export of a subset of secretory proteins, including virulence factors. The accessory Sec system consists of a second SecA paralog, termed SecA2, with or without a second SecY paralog, termed SecY2. In some bacteria, the accessory Sec system is dependent on the canonical Sec system for functionality, while in other bacteria, they can function independently. In this review, we provide an overview of the current knowledge of the canonical and accessory Sec system of Gram-positive bacteria with a focus on the primary component of the Sec translocase, SecA and SecYEG.
KW - TRANSLOCATION ATPASE SECA
KW - BINDING PROTEIN-GSPB
KW - MYCOBACTERIUM-TUBERCULOSIS SECA1
KW - SIGNAL-SEQUENCE RECOGNITION
KW - LARGE CONFORMATIONAL-CHANGE
KW - RICH REPEAT GLYCOPROTEIN
KW - BACILLUS-SUBTILIS SECA
KW - X-RAY-STRUCTURE
KW - ESCHERICHIA-COLI
KW - STREPTOCOCCUS-GORDONII
U2 - 10.1007/82_2016_9
DO - 10.1007/82_2016_9
M3 - Chapter
SN - 978-3-319-56012-0
T3 - Current Topics in Microbiology and Immunology
SP - 45
EP - 67
BT - Protein and Sugar Export and Assembly in Gram-positive Bacteria
A2 - Bagnoli, F
A2 - Rappuoli, R
PB - Springer International Publishing
CY - Cham, Switzerland
ER -