Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53

Maarten Niemantsverdriet; Edwin de Jong; Johannes A. Langendijk; Harm H. Kampinga; Robert P. Coppes

doi:10.1016/j.radonc.2010.04.002

Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53

Maarten Niemantsverdriet, Edwin de Jong, Johannes A. Langendijk, Harm H. Kampinga, Robert P. Coppes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Radiation-induced fibrosis is a severe side effect of radiotherapy. TGF-beta and radiation synergistically induce expression of the profibrotic PAI-1 gene and this cooperation potentially involves p53. Here, we demonstrate that p53 is both indispensable and sufficient for the radiation effect inducing synergistic activation of PAI-1 by radiation and TGF-beta. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 33-35

Original language	English
Pages (from-to)	33-35
Number of pages	3
Journal	Radiotherapy and Oncology
Volume	97
Issue number	1
DOIs	https://doi.org/10.1016/j.radonc.2010.04.002
Publication status	Published - Oct-2010

Keywords

P53
Radiation
TGF-beta
PAI-1
Fibrosis
INDUCED FIBROSIS
CELL-LINES
GENE
GROWTH
PHOSPHORYLATION
ACTIVATION
RESPONSES
PATHWAY
MICE

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Synergistic induction of profibrotic PAI-1 by TGF-β and radiation depends on p53Final publisher's version, 333 KBLicence: Taverne

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@article{0a23e779df3b4a78aab6892ce30dd4e5,

title = "Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53",

abstract = "Radiation-induced fibrosis is a severe side effect of radiotherapy. TGF-beta and radiation synergistically induce expression of the profibrotic PAI-1 gene and this cooperation potentially involves p53. Here, we demonstrate that p53 is both indispensable and sufficient for the radiation effect inducing synergistic activation of PAI-1 by radiation and TGF-beta. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 33-35",

keywords = "P53, Radiation, TGF-beta, PAI-1, Fibrosis, INDUCED FIBROSIS, CELL-LINES, GENE, GROWTH, PHOSPHORYLATION, ACTIVATION, RESPONSES, PATHWAY, MICE",

author = "Maarten Niemantsverdriet and {de Jong}, Edwin and Langendijk, {Johannes A.} and Kampinga, {Harm H.} and Coppes, {Robert P.}",

year = "2010",

month = oct,

doi = "10.1016/j.radonc.2010.04.002",

language = "English",

volume = "97",

pages = "33--35",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "ELSEVIER IRELAND LTD",

number = "1",

}

TY - JOUR

T1 - Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53

AU - Niemantsverdriet, Maarten

AU - de Jong, Edwin

AU - Langendijk, Johannes A.

AU - Kampinga, Harm H.

AU - Coppes, Robert P.

PY - 2010/10

Y1 - 2010/10

N2 - Radiation-induced fibrosis is a severe side effect of radiotherapy. TGF-beta and radiation synergistically induce expression of the profibrotic PAI-1 gene and this cooperation potentially involves p53. Here, we demonstrate that p53 is both indispensable and sufficient for the radiation effect inducing synergistic activation of PAI-1 by radiation and TGF-beta. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 33-35

AB - Radiation-induced fibrosis is a severe side effect of radiotherapy. TGF-beta and radiation synergistically induce expression of the profibrotic PAI-1 gene and this cooperation potentially involves p53. Here, we demonstrate that p53 is both indispensable and sufficient for the radiation effect inducing synergistic activation of PAI-1 by radiation and TGF-beta. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 97 (2010) 33-35

KW - P53

KW - Radiation

KW - TGF-beta

KW - PAI-1

KW - Fibrosis

KW - INDUCED FIBROSIS

KW - CELL-LINES

KW - GENE

KW - GROWTH

KW - PHOSPHORYLATION

KW - ACTIVATION

KW - RESPONSES

KW - PATHWAY

KW - MICE

U2 - 10.1016/j.radonc.2010.04.002

DO - 10.1016/j.radonc.2010.04.002

M3 - Article

SN - 0167-8140

VL - 97

SP - 33

EP - 35

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 1

ER -

Synergistic induction of profibrotic PAI-1 by TGF-beta and radiation depends on p53

Abstract

Keywords

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