Studies on tableting properties of lactose: VIII. The effect of variations in primary particle size, percentage of amorphous lactose and addition of a disintegrant on the disintegration of spray-dried lactose tablets

H. Vromans; G. K.  Bolhuis; C. F.  Lerk; K. D. Kussendrager

doi:10.1016/0378-5173(87)90217-1

Studies on tableting properties of lactose: VIII. The effect of variations in primary particle size, percentage of amorphous lactose and addition of a disintegrant on the disintegration of spray-dried lactose tablets

H. Vromans^*, G. K. Bolhuis, C. F. Lerk, K. D. Kussendrager

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

Disintegration of tablets compacted from spray-dried lactose samples was found to depend on the amount of amorphous lactose, the size of the primary particles and the compaction load, respectively. The poor disintegration properties of amorphous lactose was explained by pointing to the dissolution characteristics of the substance. Considerable improvement of the disintegration properties can be obtained by addition of suitable disintegrants

Original language	English
Pages (from-to)	201-206
Number of pages	6
Journal	International Journal of Pharmaceutics
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/0378-5173(87)90217-1
Publication status	Published - Oct-1987

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Vromans, H., Bolhuis, G. K., Lerk, C. F., & Kussendrager, K. D. (1987). Studies on tableting properties of lactose: VIII. The effect of variations in primary particle size, percentage of amorphous lactose and addition of a disintegrant on the disintegration of spray-dried lactose tablets. International Journal of Pharmaceutics, 39(3), 201-206. https://doi.org/10.1016/0378-5173(87)90217-1

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abstract = "Disintegration of tablets compacted from spray-dried lactose samples was found to depend on the amount of amorphous lactose, the size of the primary particles and the compaction load, respectively. The poor disintegration properties of amorphous lactose was explained by pointing to the dissolution characteristics of the substance. Considerable improvement of the disintegration properties can be obtained by addition of suitable disintegrants",

author = "H. Vromans and Bolhuis, {G. K.} and Lerk, {C. F.} and Kussendrager, {K. D.}",

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Vromans, H, Bolhuis, GK, Lerk, CF & Kussendrager, KD 1987, 'Studies on tableting properties of lactose: VIII. The effect of variations in primary particle size, percentage of amorphous lactose and addition of a disintegrant on the disintegration of spray-dried lactose tablets', International Journal of Pharmaceutics, vol. 39, no. 3, pp. 201-206. https://doi.org/10.1016/0378-5173(87)90217-1

Studies on tableting properties of lactose: VIII. The effect of variations in primary particle size, percentage of amorphous lactose and addition of a disintegrant on the disintegration of spray-dried lactose tablets. / Vromans, H.; Bolhuis, G. K.; Lerk, C. F. et al.
In: International Journal of Pharmaceutics, Vol. 39, No. 3, 10.1987, p. 201-206.

Research output: Contribution to journal › Article › Academic › peer-review

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