Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

Alex F. De Vos; Debby A.J. Van Riel; Marjan Van Meurs; Herbert P.M. Brok; Louis Boon; Rogier Q. Hintzen; Eric Claassen; Bert A. 't Hart; Jon D. Laman

doi:10.1016/j.jneuroim.2004.12.002

Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

Alex F. De Vos, Debby A.J. Van Riel, Marjan Van Meurs, Herbert P.M. Brok, Louis Boon, Rogier Q. Hintzen, Eric Claassen, Bert A. 't Hart, Jon D. Laman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.

Original language	English
Pages (from-to)	29-39
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	161
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.12.002
Publication status	Published - Apr-2005
Externally published	Yes

Keywords

Autoimmunity
Lymphoid organ
Lymphopenia
Multiple sclerosis
Myelin oligodendrocyte glycoprotein
Non-human primate

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10.1016/j.jneuroim.2004.12.002

Severe T-cell depletion from the PALSFinal publisher's version, 2.32 MBLicence: Taverne

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De Vos, A. F., Van Riel, D. A. J., Van Meurs, M., Brok, H. P. M., Boon, L., Hintzen, R. Q., Claassen, E., 't Hart, B. A., & Laman, J. D. (2005). Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE). Journal of Neuroimmunology, 161(1-2), 29-39. https://doi.org/10.1016/j.jneuroim.2004.12.002

@article{0b7e54bdce8f4ba4b1a0b09ffb81fe04,

title = "Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)",

abstract = "Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.",

keywords = "Autoimmunity, Lymphoid organ, Lymphopenia, Multiple sclerosis, Myelin oligodendrocyte glycoprotein, Non-human primate",

author = "{De Vos}, {Alex F.} and {Van Riel}, {Debby A.J.} and {Van Meurs}, Marjan and Brok, {Herbert P.M.} and Louis Boon and Hintzen, {Rogier Q.} and Eric Claassen and {'t Hart}, {Bert A.} and Laman, {Jon D.}",

year = "2005",

month = apr,

doi = "10.1016/j.jneuroim.2004.12.002",

language = "English",

volume = "161",

pages = "29--39",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "ELSEVIER SCIENCE BV",

number = "1-2",

}

De Vos, AF, Van Riel, DAJ, Van Meurs, M, Brok, HPM, Boon, L, Hintzen, RQ, Claassen, E, 't Hart, BA & Laman, JD 2005, 'Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)', Journal of Neuroimmunology, vol. 161, no. 1-2, pp. 29-39. https://doi.org/10.1016/j.jneuroim.2004.12.002

TY - JOUR

T1 - Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

AU - De Vos, Alex F.

AU - Van Riel, Debby A.J.

AU - Van Meurs, Marjan

AU - Brok, Herbert P.M.

AU - Boon, Louis

AU - Hintzen, Rogier Q.

AU - Claassen, Eric

AU - 't Hart, Bert A.

AU - Laman, Jon D.

PY - 2005/4

Y1 - 2005/4

N2 - Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.

AB - Recent data suggest that the spleen is a crucial component of the immune system in the development of experimental autoimmune encephalomyelitis (EAE) in marmoset monkeys. Using immunohistochemistry, we investigated changes in the distribution of leukocytes in the spleen associated with clinical symptoms of EAE. Animals without EAE displayed well-developed T- and B-cell areas, germinal centers and red pulp. In contrast, a marked depletion of periarteriolar T cells with preservation of other elements was found in animals with clinical EAE. These findings suggest that immune responses within the spleen are impaired during a paralysing inflammatory process in the central nervous system.

KW - Autoimmunity

KW - Lymphoid organ

KW - Lymphopenia

KW - Multiple sclerosis

KW - Myelin oligodendrocyte glycoprotein

KW - Non-human primate

U2 - 10.1016/j.jneuroim.2004.12.002

DO - 10.1016/j.jneuroim.2004.12.002

M3 - Article

C2 - 15748941

AN - SCOPUS:14844323664

SN - 0165-5728

VL - 161

SP - 29

EP - 39

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Severe T-cell depletion from the PALS leads to altered spleen composition in common marmosets with experimental autoimmune encephalomyelitis (EAE)

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Keywords

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