Safir-i: Design and performance of a high-rate preclinical pet insert for mri

Pascal Bebié; Robert Becker; Volker Commichau; Jan Debus; Günther Dissertori; Lubomir Djambazov; Afroditi Eleftheriou; Jannis Fischer; Peter Fischer; Mikiko Ito; Parisa Khateri; Werner Lustermann; Christian Ritzer; Michael Ritzert; Ulf Röser; Charalampos Tsoumpas; Geoffrey Warnock; Bruno Weber; Matthias T. Wyss; Agnieszka Zagozdzinska-Bochenek

doi:10.3390/s21217037

Safir-i: Design and performance of a high-rate preclinical pet insert for mri

Pascal Bebié^*, Robert Becker, Volker Commichau, Jan Debus, Günther Dissertori, Lubomir Djambazov, Afroditi Eleftheriou, Jannis Fischer, Peter Fischer, Mikiko Ito, Parisa Khateri, Werner Lustermann, Christian Ritzer, Michael Ritzert, Ulf Röser, Charalampos Tsoumpas, Geoffrey Warnock, Bruno Weber, Matthias T. Wyss, Agnieszka Zagozdzinska-Bochenek

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7 T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500 MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2 mm and an inner diameter of 114 mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system’s Coincidence Resolving Time (CRT) and energy resolution are between (209.0 ± 0.3) ps and (12.41 ± 0.02) % Full Width at Half Maximum (FWHM) at low activity and (326.89 ± 0.12) ps and (20.630 ± 0.011) % FWHM at 550 MBq, respectively. The peak sensitivity is ∼1.6 %. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300 MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2 mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500 MBq.

Original language	English
Article number	7037
Number of pages	27
Journal	Sensors
Volume	21
Issue number	21
DOIs	https://doi.org/10.3390/s21217037
Publication status	Published - 1-Nov-2021
Externally published	Yes

Keywords

5 s time frames
Dynamic PET/MR imaging
High frame rates
MRI
PET detector
PET insert
Preclinical PET/MRI
Temporal resolution

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SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRIFinal publisher's version, 17 MBLicence: CC BY

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Bebié, P., Becker, R., Commichau, V., Debus, J., Dissertori, G., Djambazov, L., Eleftheriou, A., Fischer, J., Fischer, P., Ito, M., Khateri, P., Lustermann, W., Ritzer, C., Ritzert, M., Röser, U., Tsoumpas, C., Warnock, G., Weber, B., Wyss, M. T., & Zagozdzinska-Bochenek, A. (2021). Safir-i: Design and performance of a high-rate preclinical pet insert for mri. Sensors, 21(21), Article 7037. https://doi.org/10.3390/s21217037

@article{81dbe645fc3c48928cbd4ca3822bf6ab,

title = "Safir-i: Design and performance of a high-rate preclinical pet insert for mri",

abstract = "(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7 T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500 MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2 mm and an inner diameter of 114 mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system{\textquoteright}s Coincidence Resolving Time (CRT) and energy resolution are between (209.0 ± 0.3) ps and (12.41 ± 0.02) % Full Width at Half Maximum (FWHM) at low activity and (326.89 ± 0.12) ps and (20.630 ± 0.011) % FWHM at 550 MBq, respectively. The peak sensitivity is ∼1.6 %. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300 MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2 mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500 MBq.",

keywords = "5 s time frames, Dynamic PET/MR imaging, High frame rates, MRI, PET detector, PET insert, Preclinical PET/MRI, Temporal resolution",

author = "Pascal Bebi{\'e} and Robert Becker and Volker Commichau and Jan Debus and G{\"u}nther Dissertori and Lubomir Djambazov and Afroditi Eleftheriou and Jannis Fischer and Peter Fischer and Mikiko Ito and Parisa Khateri and Werner Lustermann and Christian Ritzer and Michael Ritzert and Ulf R{\"o}ser and Charalampos Tsoumpas and Geoffrey Warnock and Bruno Weber and Wyss, {Matthias T.} and Agnieszka Zagozdzinska-Bochenek",

note = "Funding Information: This research was supported by the ETH Research Grant ETH-30 14-2, partly borne by the ETH Foundation under project number 2015-03, and by the Einrichtungskredit of the University of Zurich. Charalampos Tsoumpas was sponsored by a Royal Society Industry Fellowship (IF170011). The authors thank the Radiopharmaceutical Science group of R. Schibli at ETH Zurich for providing the18 F, and the University Hospital of Zurich for supplying the FDG. Funding Information: Funding: This research was supported by the ETH Research Grant ETH-30 14-2, partly borne by the ETH Foundation under project number 2015-03, and by the Einrichtungskredit of the University of Zurich. Charalampos Tsoumpas was sponsored by a Royal Society Industry Fellowship (IF170011). Publisher Copyright: {\textcopyright} 2021 by the authors. Li-censee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

day = "1",

doi = "10.3390/s21217037",

language = "English",

volume = "21",

journal = "Sensors",

issn = "1424-8220",

publisher = "MDPI AG",

number = "21",

}

Bebié, P, Becker, R, Commichau, V, Debus, J, Dissertori, G, Djambazov, L, Eleftheriou, A, Fischer, J, Fischer, P, Ito, M, Khateri, P, Lustermann, W, Ritzer, C, Ritzert, M, Röser, U, Tsoumpas, C, Warnock, G, Weber, B, Wyss, MT & Zagozdzinska-Bochenek, A 2021, 'Safir-i: Design and performance of a high-rate preclinical pet insert for mri', Sensors, vol. 21, no. 21, 7037. https://doi.org/10.3390/s21217037

TY - JOUR

T1 - Safir-i

T2 - Design and performance of a high-rate preclinical pet insert for mri

AU - Bebié, Pascal

AU - Becker, Robert

AU - Commichau, Volker

AU - Debus, Jan

AU - Dissertori, Günther

AU - Djambazov, Lubomir

AU - Eleftheriou, Afroditi

AU - Fischer, Jannis

AU - Fischer, Peter

AU - Ito, Mikiko

AU - Khateri, Parisa

AU - Lustermann, Werner

AU - Ritzer, Christian

AU - Ritzert, Michael

AU - Röser, Ulf

AU - Tsoumpas, Charalampos

AU - Warnock, Geoffrey

AU - Weber, Bruno

AU - Wyss, Matthias T.

AU - Zagozdzinska-Bochenek, Agnieszka

N1 - Funding Information: This research was supported by the ETH Research Grant ETH-30 14-2, partly borne by the ETH Foundation under project number 2015-03, and by the Einrichtungskredit of the University of Zurich. Charalampos Tsoumpas was sponsored by a Royal Society Industry Fellowship (IF170011). The authors thank the Radiopharmaceutical Science group of R. Schibli at ETH Zurich for providing the18 F, and the University Hospital of Zurich for supplying the FDG. Funding Information: Funding: This research was supported by the ETH Research Grant ETH-30 14-2, partly borne by the ETH Foundation under project number 2015-03, and by the Einrichtungskredit of the University of Zurich. Charalampos Tsoumpas was sponsored by a Royal Society Industry Fellowship (IF170011). Publisher Copyright: © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.

PY - 2021/11/1

Y1 - 2021/11/1

N2 - (1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7 T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500 MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2 mm and an inner diameter of 114 mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system’s Coincidence Resolving Time (CRT) and energy resolution are between (209.0 ± 0.3) ps and (12.41 ± 0.02) % Full Width at Half Maximum (FWHM) at low activity and (326.89 ± 0.12) ps and (20.630 ± 0.011) % FWHM at 550 MBq, respectively. The peak sensitivity is ∼1.6 %. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300 MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2 mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500 MBq.

AB - (1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7 T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500 MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2 mm and an inner diameter of 114 mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system’s Coincidence Resolving Time (CRT) and energy resolution are between (209.0 ± 0.3) ps and (12.41 ± 0.02) % Full Width at Half Maximum (FWHM) at low activity and (326.89 ± 0.12) ps and (20.630 ± 0.011) % FWHM at 550 MBq, respectively. The peak sensitivity is ∼1.6 %. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300 MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2 mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500 MBq.

KW - 5 s time frames

KW - Dynamic PET/MR imaging

KW - High frame rates

KW - MRI

KW - PET detector

KW - PET insert

KW - Preclinical PET/MRI

KW - Temporal resolution

U2 - 10.3390/s21217037

DO - 10.3390/s21217037

M3 - Article

AN - SCOPUS:85117579990

SN - 1424-8220

VL - 21

JO - Sensors

JF - Sensors

IS - 21

M1 - 7037

ER -

Safir-i: Design and performance of a high-rate preclinical pet insert for mri

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