TY - JOUR
T1 - Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure A Scientific Statement From the American Heart Association
AU - Chow, Sheryl L.
AU - Maisel, Alan S.
AU - Anand, Inder
AU - Bozkurt, Biykem
AU - de Boer, Rudolf A.
AU - Felker, G. Michael
AU - Fonarow, Gregg C.
AU - Greenberg, Barry
AU - Januzzi, James L.
AU - Kiernan, Michael S.
AU - Liu, Peter P.
AU - Wang, Thomas J.
AU - Yancy, Clyde W.
AU - Zile, Michael R.
AU - Amer Heart Assoc Clinical Pharmac
AU - Council Basic Cardiovascular Sci
AU - Council Cardiovascular Dis Young
AU - Council Cardiovascular & Stroke
AU - Council Cardiopulmonary Critical
AU - Council Epidemiology & Prevention
AU - Council Functional Genomics
AU - Council Quality Care Out Comes Res
PY - 2017/5/30
Y1 - 2017/5/30
N2 - BACKGROUND AND PURPOSE: Natriuretic peptides have led the way as a diagnostic and prognostic tool for the diagnosis and management of heart failure (HF). More recent evidence suggests that natriuretic peptides along with the next generation of biomarkers may provide added value to medical management, which could potentially lower risk of mortality and readmissions. The purpose of this scientific statement is to summarize the existing literature and to provide guidance for the utility of currently available biomarkers.METHODS: The writing group used systematic literature reviews, published translational and clinical studies, clinical practice guidelines, and expert opinion/statements to summarize existing evidence and to identify areas of inadequacy requiring future research. The panel reviewed the most relevant adult medical literature excluding routine laboratory tests using MEDLINE, EMBASE, and Web of Science through December 2016. The document is organized and classified according to the American Heart Association to provide specific suggestions, considerations, or contemporary clinical practice recommendations.RESULTS: A number of biomarkers associated with HF are well recognized, and measuring their concentrations in circulation can be a convenient and noninvasive approach to provide important information about disease severity and helps in the detection, diagnosis, prognosis, and management of HF. These include natriuretic peptides, soluble suppressor of tumorgenicity 2, highly sensitive troponin, galectin-3, midregional proadrenomedullin, cystatin-C, interleukin-6, procalcitonin, and others. There is a need to further evaluate existing and novel markers for guiding therapy and to summarize their data in a standardized format to improve communication among researchers and practitioners.CONCLUSIONS: HF is a complex syndrome involving diverse pathways and pathological processes that can manifest in circulation as biomarkers. A number of such biomarkers are now clinically available, and monitoring their concentrations in blood not only can provide the clinician information about the diagnosis and severity of HF but also can improve prognostication and treatment strategies.
AB - BACKGROUND AND PURPOSE: Natriuretic peptides have led the way as a diagnostic and prognostic tool for the diagnosis and management of heart failure (HF). More recent evidence suggests that natriuretic peptides along with the next generation of biomarkers may provide added value to medical management, which could potentially lower risk of mortality and readmissions. The purpose of this scientific statement is to summarize the existing literature and to provide guidance for the utility of currently available biomarkers.METHODS: The writing group used systematic literature reviews, published translational and clinical studies, clinical practice guidelines, and expert opinion/statements to summarize existing evidence and to identify areas of inadequacy requiring future research. The panel reviewed the most relevant adult medical literature excluding routine laboratory tests using MEDLINE, EMBASE, and Web of Science through December 2016. The document is organized and classified according to the American Heart Association to provide specific suggestions, considerations, or contemporary clinical practice recommendations.RESULTS: A number of biomarkers associated with HF are well recognized, and measuring their concentrations in circulation can be a convenient and noninvasive approach to provide important information about disease severity and helps in the detection, diagnosis, prognosis, and management of HF. These include natriuretic peptides, soluble suppressor of tumorgenicity 2, highly sensitive troponin, galectin-3, midregional proadrenomedullin, cystatin-C, interleukin-6, procalcitonin, and others. There is a need to further evaluate existing and novel markers for guiding therapy and to summarize their data in a standardized format to improve communication among researchers and practitioners.CONCLUSIONS: HF is a complex syndrome involving diverse pathways and pathological processes that can manifest in circulation as biomarkers. A number of such biomarkers are now clinically available, and monitoring their concentrations in blood not only can provide the clinician information about the diagnosis and severity of HF but also can improve prognostication and treatment strategies.
KW - AHA Scientific Statements
KW - biomarkers
KW - diagnosis
KW - heart failure
KW - patient care management
KW - prognosis
KW - therapeutics
KW - BRAIN-NATRIURETIC PEPTIDE
KW - PRESERVED EJECTION FRACTION
KW - CARDIAC TROPONIN-T
KW - FAMILY-MEMBER ST2
KW - LEFT-VENTRICULAR DYSFUNCTION
KW - HIGH-SENSITIVITY TROPONIN
KW - WORSENING RENAL-FUNCTION
KW - LONG-TERM MORTALITY
KW - INCREASED SERUM CONCENTRATIONS
KW - INITIATE LIFESAVING TREATMENT
U2 - 10.1161/CIR.0000000000000490
DO - 10.1161/CIR.0000000000000490
M3 - Article
SN - 0009-7322
VL - 135
SP - E1054-E1091
JO - Circulation
JF - Circulation
IS - 22
ER -