Risk factors of HCV seroconversion in hemodialysis patients in tabriz, iran

Mohammad Hossein Somi; Jalal Etemadi; Morteza Ghojazadeh; Sara Farhang; Mehrasa Faramarzi; Sanaz Foroutan; Maryam Soleimanpour

doi:10.5812/hepatmon.17417

Risk factors of HCV seroconversion in hemodialysis patients in tabriz, iran

Mohammad Hossein Somi, Jalal Etemadi, Morteza Ghojazadeh, Sara Farhang, Mehrasa Faramarzi, Sanaz Foroutan, Maryam Soleimanpour

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Abstract

BACKGROUND: Hepatitis C virus (HCV) infection is a significant health concern in patients with end-stage renal disease under dialysis. Epidemiological studies have reported a prevalence rate of 5.5-55.9% for this condition in Iran.

OBJECTIVES: We evaluated the risk factors for HCV infection and seroconversion in hemodialysis patients.

PATIENTS AND METHODS: A retrospective analysis was performed on 455 hemodialysis patients from each of the five dialysis units in Tabriz, northwest Iran. Possible risk factors for HCV infection and seroconversion were evaluated.

RESULTS: A total of 37 patients were HCV positive (8.1% of the study population) and seroconversion occurred in 18 of them during the dialysis treatment (3.95% of the study population). History of renal transplantation (44.4%, P < 0.0001), surgical intervention (except for renal transplantation and AV fistula placement) (94.4%, P = 0.03), and mean duration of dialysis (106.06 ± 55.519, P < 0.0001) had strong statistically significant associations with the seroconversion.

CONCLUSIONS: The current study indicates increased risk for HCV infection in patients under dialysis and its relation with the mean duration of hemodialysis, history of renal transplantation and surgical intervention. Considering the immune deficiency in these patients, intense education to both patients and medical staff will be beneficial.

Original language	English
Article number	e17417
Journal	Hepatitis monthly
Volume	14
Issue number	6
DOIs	https://doi.org/10.5812/hepatmon.17417
Publication status	Published - Jun-2014
Externally published	Yes

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Journal Article

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Risk Factors of HCV Seroconversion in Hemodialysis Patients in TabrizFinal publisher's version, 96.6 KBLicence: CC BY-NC

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title = "Risk factors of HCV seroconversion in hemodialysis patients in tabriz, iran",

abstract = "BACKGROUND: Hepatitis C virus (HCV) infection is a significant health concern in patients with end-stage renal disease under dialysis. Epidemiological studies have reported a prevalence rate of 5.5-55.9% for this condition in Iran.OBJECTIVES: We evaluated the risk factors for HCV infection and seroconversion in hemodialysis patients.PATIENTS AND METHODS: A retrospective analysis was performed on 455 hemodialysis patients from each of the five dialysis units in Tabriz, northwest Iran. Possible risk factors for HCV infection and seroconversion were evaluated.RESULTS: A total of 37 patients were HCV positive (8.1% of the study population) and seroconversion occurred in 18 of them during the dialysis treatment (3.95% of the study population). History of renal transplantation (44.4%, P < 0.0001), surgical intervention (except for renal transplantation and AV fistula placement) (94.4%, P = 0.03), and mean duration of dialysis (106.06 ± 55.519, P < 0.0001) had strong statistically significant associations with the seroconversion.CONCLUSIONS: The current study indicates increased risk for HCV infection in patients under dialysis and its relation with the mean duration of hemodialysis, history of renal transplantation and surgical intervention. Considering the immune deficiency in these patients, intense education to both patients and medical staff will be beneficial.",

keywords = "Journal Article",

author = "Somi, {Mohammad Hossein} and Jalal Etemadi and Morteza Ghojazadeh and Sara Farhang and Mehrasa Faramarzi and Sanaz Foroutan and Maryam Soleimanpour",

year = "2014",

month = jun,

doi = "10.5812/hepatmon.17417",

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volume = "14",

journal = "Hepatitis monthly",

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TY - JOUR

T1 - Risk factors of HCV seroconversion in hemodialysis patients in tabriz, iran

AU - Somi, Mohammad Hossein

AU - Etemadi, Jalal

AU - Ghojazadeh, Morteza

AU - Farhang, Sara

AU - Faramarzi, Mehrasa

AU - Foroutan, Sanaz

AU - Soleimanpour, Maryam

PY - 2014/6

Y1 - 2014/6

N2 - BACKGROUND: Hepatitis C virus (HCV) infection is a significant health concern in patients with end-stage renal disease under dialysis. Epidemiological studies have reported a prevalence rate of 5.5-55.9% for this condition in Iran.OBJECTIVES: We evaluated the risk factors for HCV infection and seroconversion in hemodialysis patients.PATIENTS AND METHODS: A retrospective analysis was performed on 455 hemodialysis patients from each of the five dialysis units in Tabriz, northwest Iran. Possible risk factors for HCV infection and seroconversion were evaluated.RESULTS: A total of 37 patients were HCV positive (8.1% of the study population) and seroconversion occurred in 18 of them during the dialysis treatment (3.95% of the study population). History of renal transplantation (44.4%, P < 0.0001), surgical intervention (except for renal transplantation and AV fistula placement) (94.4%, P = 0.03), and mean duration of dialysis (106.06 ± 55.519, P < 0.0001) had strong statistically significant associations with the seroconversion.CONCLUSIONS: The current study indicates increased risk for HCV infection in patients under dialysis and its relation with the mean duration of hemodialysis, history of renal transplantation and surgical intervention. Considering the immune deficiency in these patients, intense education to both patients and medical staff will be beneficial.

AB - BACKGROUND: Hepatitis C virus (HCV) infection is a significant health concern in patients with end-stage renal disease under dialysis. Epidemiological studies have reported a prevalence rate of 5.5-55.9% for this condition in Iran.OBJECTIVES: We evaluated the risk factors for HCV infection and seroconversion in hemodialysis patients.PATIENTS AND METHODS: A retrospective analysis was performed on 455 hemodialysis patients from each of the five dialysis units in Tabriz, northwest Iran. Possible risk factors for HCV infection and seroconversion were evaluated.RESULTS: A total of 37 patients were HCV positive (8.1% of the study population) and seroconversion occurred in 18 of them during the dialysis treatment (3.95% of the study population). History of renal transplantation (44.4%, P < 0.0001), surgical intervention (except for renal transplantation and AV fistula placement) (94.4%, P = 0.03), and mean duration of dialysis (106.06 ± 55.519, P < 0.0001) had strong statistically significant associations with the seroconversion.CONCLUSIONS: The current study indicates increased risk for HCV infection in patients under dialysis and its relation with the mean duration of hemodialysis, history of renal transplantation and surgical intervention. Considering the immune deficiency in these patients, intense education to both patients and medical staff will be beneficial.

KW - Journal Article

U2 - 10.5812/hepatmon.17417

DO - 10.5812/hepatmon.17417

M3 - Article

C2 - 24976839

SN - 1735-143X

VL - 14

JO - Hepatitis monthly

JF - Hepatitis monthly

IS - 6

M1 - e17417

ER -

Risk factors of HCV seroconversion in hemodialysis patients in tabriz, iran

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