Abstract
In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesn't inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.
| Original language | English |
|---|---|
| Pages (from-to) | 339-348 |
| Number of pages | 10 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 6 |
| Issue number | 3 |
| Publication status | Published - Mar-2006 |
Keywords
- airway remodelling
- airway smooth muscle
- airway inflammation
- Y-27632
- fasudil
- SMOOTH-MUSCLE-CELLS
- EXTRACELLULAR-MATRIX PROTEINS
- POTENTIAL THERAPEUTIC TARGET
- SERUM RESPONSE FACTOR
- GENE-EXPRESSION
- CA2+ SENSITIZATION
- ACTIN POLYMERIZATION
- CYSTEINYL LEUKOTRIENES
- NUCLEAR TRANSLOCATION
- INTRAOCULAR-PRESSURE