TY - JOUR
T1 - Renal function as a predictor of outcome in a broad spectrum of patients with heart failure
AU - Hillege, HL
AU - Nitsch, D
AU - Pfeffer, MA
AU - Swedberg, K
AU - McMurray, JJV
AU - Yusuf, S
AU - Granger, CB
AU - Michelson, EL
AU - Ostergren, J
AU - Cornel, JH
AU - de Zeeuw, D
AU - Pocock, S
AU - van Veldhuisen, DJ
AU - Candesartan Heart Failure
N1 - 8 Article J
PY - 2006/2/7
Y1 - 2006/2/7
N2 - Background - Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) with markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was to evaluate the prognostic importance of renal function in a broader spectrum of patients with CHF.Methods and Results - The Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program consisted of three component trials that enrolled patients with symptomatic CHF, based on use of ACE inhibitors and reduced ( 40%). Entry baseline creatinine was required to be below 3.0 mg/dL (265 mu mol/L). Routine baseline serum creatinine assessments were done in 2680 North American patients. An analysis of the estimated glomerular filtration rate (eGFR), using the Modification of Diet in Renal Disease equation and LVEF on risk of cardiovascular death or hospitalization for heart failure, as well as on all-cause mortality, was conducted on these 2680 patients. The proportion of patients with eGFR <60 mL/min per 1.73 m(2) was 36.0%; 42.6% for CHARM-Alternative, 33.0% for CHARM-Added, and 34.7% for CHARM-Preserved. During the median follow-up of 34.4 months (total 6493 person-years), the primary outcome of cardiovascular death or hospital admission for worsening CHF occurred in 950 of 2680 subjects. Both reduced eGFR and lower LVEF were found to be significant independent predictors of worse outcome after adjustment for major confounding baseline clinical characteristics. The risk for cardiovascular death or hospitalization for worsening CHF as well as the risk for all-cause mortality increased significantly below an eGFR of 60 mL/min per 1.73 m(2) (adjusted hazard ratio, 1.54 for 45 to 60 mL/min per 1.73 m(2) and 1.86 for <45 mL/min per 1.73 m(2) for the primary outcome, both P <0.001, and hazard ratio of 1.50, P = 0.006, and 1.91, P = 0.001, respectively, for all-cause mortality). The prognostic value of eGFR was not significantly different among the three component trials. There was no significant interaction between renal function, the effect of candesartan, and clinical outcome.Conclusions - Impaired renal function is independently associated with heightened risk for death, cardiovascular death, and hospitalization for heart failure in patients with CHF with both preserved as well as reduced LVEF. There was no evidence that the beneficial effect of candesartan was modified by baseline eGFR.
AB - Background - Decreased renal function has been found to be an independent risk factor for cardiovascular outcomes in patients with chronic heart failure (CHF) with markedly reduced left ventricular ejection fraction (LVEF). The aim of this analysis was to evaluate the prognostic importance of renal function in a broader spectrum of patients with CHF.Methods and Results - The Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program consisted of three component trials that enrolled patients with symptomatic CHF, based on use of ACE inhibitors and reduced ( 40%). Entry baseline creatinine was required to be below 3.0 mg/dL (265 mu mol/L). Routine baseline serum creatinine assessments were done in 2680 North American patients. An analysis of the estimated glomerular filtration rate (eGFR), using the Modification of Diet in Renal Disease equation and LVEF on risk of cardiovascular death or hospitalization for heart failure, as well as on all-cause mortality, was conducted on these 2680 patients. The proportion of patients with eGFR <60 mL/min per 1.73 m(2) was 36.0%; 42.6% for CHARM-Alternative, 33.0% for CHARM-Added, and 34.7% for CHARM-Preserved. During the median follow-up of 34.4 months (total 6493 person-years), the primary outcome of cardiovascular death or hospital admission for worsening CHF occurred in 950 of 2680 subjects. Both reduced eGFR and lower LVEF were found to be significant independent predictors of worse outcome after adjustment for major confounding baseline clinical characteristics. The risk for cardiovascular death or hospitalization for worsening CHF as well as the risk for all-cause mortality increased significantly below an eGFR of 60 mL/min per 1.73 m(2) (adjusted hazard ratio, 1.54 for 45 to 60 mL/min per 1.73 m(2) and 1.86 for <45 mL/min per 1.73 m(2) for the primary outcome, both P <0.001, and hazard ratio of 1.50, P = 0.006, and 1.91, P = 0.001, respectively, for all-cause mortality). The prognostic value of eGFR was not significantly different among the three component trials. There was no significant interaction between renal function, the effect of candesartan, and clinical outcome.Conclusions - Impaired renal function is independently associated with heightened risk for death, cardiovascular death, and hospitalization for heart failure in patients with CHF with both preserved as well as reduced LVEF. There was no evidence that the beneficial effect of candesartan was modified by baseline eGFR.
KW - heart failure
KW - angiotensin
KW - kidney
KW - risk factors
KW - prognosis
KW - GLOMERULAR-FILTRATION-RATE
KW - VENTRICULAR SYSTOLIC FUNCTION
KW - CONVERTING-ENZYME INHIBITORS
KW - MYOCARDIAL-INFARCTION
KW - CARDIOVASCULAR OUTCOMES
KW - KIDNEY-FUNCTION
KW - TRIAL
KW - INSUFFICIENCY
KW - MORTALITY
KW - RISK
U2 - 10.1161/CIRCULATIONAHA.105.580506
DO - 10.1161/CIRCULATIONAHA.105.580506
M3 - Article
SN - 0009-7322
VL - 113
SP - 671
EP - 678
JO - Circulation
JF - Circulation
IS - 5
ER -