Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial

Fernanda Vicioni-Marques; Francisco Wanderley Garcia de Paula-Silva; Milena Rodrigues Carvalho; Alexandra Mussolino de Queiroz; Osvaldo de Freitas; Maíra Peres Ferreira Duarte; David John Manton; Fabrício Kitazono de Carvalho

doi:10.1590/1678-7757-2021-0538

Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial

Fernanda Vicioni-Marques, Francisco Wanderley Garcia de Paula-Silva, Milena Rodrigues Carvalho, Alexandra Mussolino de Queiroz, Osvaldo de Freitas, Maíra Peres Ferreira Duarte, David John Manton, Fabrício Kitazono de Carvalho

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia.

OBJECTIVE: This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity.

METHODOLOGY: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher's exact test, and t-test.

RESULTS: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure.

CONCLUSION: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.

Original language	English
Article number	e20210538
Number of pages	6
Journal	Journal of Applied Oral Science
Volume	30
DOIs	https://doi.org/10.1590/1678-7757-2021-0538
Publication status	Published - 2022

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Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molarFinal publisher's version, 610 KBLicence: CC BY

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Vicioni-Marques, F., Paula-Silva, F. W. G. D., Carvalho, M. R., Queiroz, A. M. D., Freitas, O. D., Duarte, M. P. F., Manton, D. J., & Carvalho, F. K. D. (2022). Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial. Journal of Applied Oral Science, 30, Article e20210538. https://doi.org/10.1590/1678-7757-2021-0538

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title = "Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial",

abstract = "Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia.OBJECTIVE: This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity.METHODOLOGY: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher's exact test, and t-test.RESULTS: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure.CONCLUSION: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.",

author = "Fernanda Vicioni-Marques and Paula-Silva, {Francisco Wanderley Garcia de} and Carvalho, {Milena Rodrigues} and Queiroz, {Alexandra Mussolino de} and Freitas, {Osvaldo de} and Duarte, {Ma{\'i}ra Peres Ferreira} and Manton, {David John} and Carvalho, {Fabr{\'i}cio Kitazono de}",

year = "2022",

doi = "10.1590/1678-7757-2021-0538",

language = "English",

volume = "30",

journal = "Journal of Applied Oral Science",

issn = "1678-7757",

publisher = " Universidade de S{\~a}o Paulo",

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Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial. / Vicioni-Marques, Fernanda; Paula-Silva, Francisco Wanderley Garcia de; Carvalho, Milena Rodrigues et al.
In: Journal of Applied Oral Science, Vol. 30, e20210538, 2022.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar

T2 - a triple-blind randomized clinical trial

AU - Vicioni-Marques, Fernanda

AU - Paula-Silva, Francisco Wanderley Garcia de

AU - Carvalho, Milena Rodrigues

AU - Queiroz, Alexandra Mussolino de

AU - Freitas, Osvaldo de

AU - Duarte, Maíra Peres Ferreira

AU - Manton, David John

AU - Carvalho, Fabrício Kitazono de

PY - 2022

Y1 - 2022

N2 - Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia.OBJECTIVE: This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity.METHODOLOGY: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher's exact test, and t-test.RESULTS: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure.CONCLUSION: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.

AB - Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia.OBJECTIVE: This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity.METHODOLOGY: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher's exact test, and t-test.RESULTS: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure.CONCLUSION: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.

U2 - 10.1590/1678-7757-2021-0538

DO - 10.1590/1678-7757-2021-0538

M3 - Article

SN - 1678-7757

VL - 30

JO - Journal of Applied Oral Science

JF - Journal of Applied Oral Science

M1 - e20210538

ER -

Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial

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