Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial

Fernanda Vicioni-Marques, Francisco Wanderley Garcia de Paula-Silva, Milena Rodrigues Carvalho, Alexandra Mussolino de Queiroz, Osvaldo de Freitas, Maíra Peres Ferreira Duarte, David John Manton, Fabrício Kitazono de Carvalho

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    Abstract

    Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia.

    OBJECTIVE: This study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity.

    METHODOLOGY: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher's exact test, and t-test.

    RESULTS: Preemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure.

    CONCLUSION: Preemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.
    Original languageEnglish
    Article numbere20210538
    Number of pages6
    JournalJournal of Applied Oral Science
    Volume30
    DOIs
    Publication statusPublished - 2022

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