TY - JOUR
T1 - Outcomes of COVID-19 in peritoneal dialysis patients
T2 - A report by the European Renal Association COVID-19 Database
AU - ERACODA Collaborators
AU - Abrahams, Alferso C.
AU - Noordzij, Marlies
AU - Goffin, Eric
AU - Sanchez, J. Emilio
AU - Franssen, Casper F.M.
AU - Vart, Priya
AU - Jager, Kitty J.
AU - van Agteren, Madelon
AU - Covic, Adrian
AU - Mitra, Sandip
AU - Basile, Carlo
AU - Konings, Constantijn
AU - Hemmelder, Marc H.
AU - Duivenvoorden, Raphaël
AU - Hilbrands, Luuk B.
AU - Gansevoort, Ron T.
N1 - Funding Information:
The author(s) declared potential conflicts of interest with respect to the research, authorship, and/or publication of this article. SM is supported by the National Institute for Health Research at Manchester, UK, and Devices for Dignity MedTech & In vitro Diagnostics Co-operative, Sheffield, UK.
Publisher Copyright:
© The Author(s) 2021.
PY - 2023/1
Y1 - 2023/1
N2 - Background: The clinical course of COVID-19 in peritoneal dialysis (PD) patients has so far only been analysed in relatively small, often single-centre case series. Therefore, we studied patient- and disease-related characteristics and outcomes of COVID-19 in a larger European cohort of PD patients.Methods: We used data from the European Renal Association COVID-19 Database (ERACODA) on PD and haemodialysis (HD) patients with COVID-19 (presentation between February 2020 and April 2021). Hazard ratios (HR) for mortality at 3 months were calculated using Cox proportional-hazards regression. In addition, we examined functional and mental health status among survivors at this time point as determined by their treating physician.Results: Of 216 PD patients with COVID-19, 80 (37%) were not hospitalised and 136 (63%) were hospitalised, of whom 19 (8.8%) were admitted to an intensive care unit. Mortality at 3 months for these subgroups was 18%, 40%, and 37%, respectively (p = 0.0031). Compared with HD patients, PD patients had higher mortality (crude HR: 1.49; 95% CI: 1.33–1.66), even when adjusted for patient characteristics and disease severity (adjusted HR: 1.56; 95% CI: 1.39–1.75). Follow-up data on 67 of 146 patients who survived COVID-19 showed functional recovery to pre-COVID-19 levels in 52 (78%) and mental recovery in 58 patients (87%) at 3 months after the COVID-19 diagnosis.Conclusion: The mortality rate in the first 3 months after presentation with COVID-19 is high, especially among PD patients who were hospitalised. PD patients with COVID-19 had a higher mortality risk than HD patients. The majority of surviving patients recovered both functionally and mentally from COVID-19 within 3 months.
AB - Background: The clinical course of COVID-19 in peritoneal dialysis (PD) patients has so far only been analysed in relatively small, often single-centre case series. Therefore, we studied patient- and disease-related characteristics and outcomes of COVID-19 in a larger European cohort of PD patients.Methods: We used data from the European Renal Association COVID-19 Database (ERACODA) on PD and haemodialysis (HD) patients with COVID-19 (presentation between February 2020 and April 2021). Hazard ratios (HR) for mortality at 3 months were calculated using Cox proportional-hazards regression. In addition, we examined functional and mental health status among survivors at this time point as determined by their treating physician.Results: Of 216 PD patients with COVID-19, 80 (37%) were not hospitalised and 136 (63%) were hospitalised, of whom 19 (8.8%) were admitted to an intensive care unit. Mortality at 3 months for these subgroups was 18%, 40%, and 37%, respectively (p = 0.0031). Compared with HD patients, PD patients had higher mortality (crude HR: 1.49; 95% CI: 1.33–1.66), even when adjusted for patient characteristics and disease severity (adjusted HR: 1.56; 95% CI: 1.39–1.75). Follow-up data on 67 of 146 patients who survived COVID-19 showed functional recovery to pre-COVID-19 levels in 52 (78%) and mental recovery in 58 patients (87%) at 3 months after the COVID-19 diagnosis.Conclusion: The mortality rate in the first 3 months after presentation with COVID-19 is high, especially among PD patients who were hospitalised. PD patients with COVID-19 had a higher mortality risk than HD patients. The majority of surviving patients recovered both functionally and mentally from COVID-19 within 3 months.
KW - COVID-19
KW - functional health status
KW - mental health status
KW - peritoneal dialysis
KW - survival
U2 - 10.1177/08968608221144395
DO - 10.1177/08968608221144395
M3 - Article
C2 - 36647559
AN - SCOPUS:85146310248
SN - 0896-8608
VL - 43
SP - 23
EP - 36
JO - Peritoneal dialysis international
JF - Peritoneal dialysis international
IS - 1
ER -