Microbial dehalogenation

DB Janssen; JE Oppentocht; GJ Poelarends

doi:10.1016/S0958-1669(00)00208-1

Microbial dehalogenation

DB Janssen^*, JE Oppentocht, GJ Poelarends

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

171 Citations (Scopus)

506 Downloads (Pure)

Abstract

Novel dehalogenases have been identified recently in various bacteria that utilise halogenated substrates. X-ray studies and sequence analysis have revealed insight into the molecular mechanisms of hydrolytic dehalogenases. Furthermore, genetic and biochemical studies have indicated that reductive dehalogenases are extra-cytoplasmic corrinoid-containing iron-sulphur proteins. Sequence analysis and mutagenesis studies indicate that several dehalogenases are homologous to enzymes that carry out transformations on non-halogenated substrates.

Original language	English
Pages (from-to)	254-258
Number of pages	5
Journal	Current Opinion in Biotechnology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/S0958-1669(00)00208-1
Publication status	Published - Jun-2001

Keywords

SPHINGOMONAS-PAUCIMOBILIS UT26
DESULFITOBACTERIUM DEHALOGENANS
L-2-HALOACID DEHALOGENASE
HALOALKANE DEHALOGENASE
REDUCTIVE DEHALOGENASE
CRYSTAL-STRUCTURES
ENZYME
GENE
DEGRADATION
SP.

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@article{38f453b18d804b9883b67ea236a5a3ff,

title = "Microbial dehalogenation",

abstract = "Novel dehalogenases have been identified recently in various bacteria that utilise halogenated substrates. X-ray studies and sequence analysis have revealed insight into the molecular mechanisms of hydrolytic dehalogenases. Furthermore, genetic and biochemical studies have indicated that reductive dehalogenases are extra-cytoplasmic corrinoid-containing iron-sulphur proteins. Sequence analysis and mutagenesis studies indicate that several dehalogenases are homologous to enzymes that carry out transformations on non-halogenated substrates.",

keywords = "SPHINGOMONAS-PAUCIMOBILIS UT26, DESULFITOBACTERIUM DEHALOGENANS, L-2-HALOACID DEHALOGENASE, HALOALKANE DEHALOGENASE, REDUCTIVE DEHALOGENASE, CRYSTAL-STRUCTURES, ENZYME, GENE, DEGRADATION, SP.",

author = "DB Janssen and JE Oppentocht and GJ Poelarends",

year = "2001",

month = jun,

doi = "10.1016/S0958-1669(00)00208-1",

language = "English",

volume = "12",

pages = "254--258",

journal = "Current Opinion in Biotechnology",

issn = "0958-1669",

publisher = "CURRENT BIOLOGY LTD",

number = "3",

}

TY - JOUR

T1 - Microbial dehalogenation

AU - Janssen, DB

AU - Oppentocht, JE

AU - Poelarends, GJ

PY - 2001/6

Y1 - 2001/6

N2 - Novel dehalogenases have been identified recently in various bacteria that utilise halogenated substrates. X-ray studies and sequence analysis have revealed insight into the molecular mechanisms of hydrolytic dehalogenases. Furthermore, genetic and biochemical studies have indicated that reductive dehalogenases are extra-cytoplasmic corrinoid-containing iron-sulphur proteins. Sequence analysis and mutagenesis studies indicate that several dehalogenases are homologous to enzymes that carry out transformations on non-halogenated substrates.

AB - Novel dehalogenases have been identified recently in various bacteria that utilise halogenated substrates. X-ray studies and sequence analysis have revealed insight into the molecular mechanisms of hydrolytic dehalogenases. Furthermore, genetic and biochemical studies have indicated that reductive dehalogenases are extra-cytoplasmic corrinoid-containing iron-sulphur proteins. Sequence analysis and mutagenesis studies indicate that several dehalogenases are homologous to enzymes that carry out transformations on non-halogenated substrates.

KW - SPHINGOMONAS-PAUCIMOBILIS UT26

KW - DESULFITOBACTERIUM DEHALOGENANS

KW - L-2-HALOACID DEHALOGENASE

KW - HALOALKANE DEHALOGENASE

KW - REDUCTIVE DEHALOGENASE

KW - CRYSTAL-STRUCTURES

KW - ENZYME

KW - GENE

KW - DEGRADATION

KW - SP.

U2 - 10.1016/S0958-1669(00)00208-1

DO - 10.1016/S0958-1669(00)00208-1

M3 - Review article

SN - 0958-1669

VL - 12

SP - 254

EP - 258

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

IS - 3

ER -

Microbial dehalogenation

Abstract

Keywords

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