Low Lymphocyte Ratio as a Novel Prognostic Factor in Acute Heart Failure: Results from the Pre-RELAX-AHF Study

Olga Milo-Cotter; John R. Teerlink; Marco Metra; G. Michael Felker; Piotr Ponikowski; Adriaan A. Voors; Christopher Edwards; Beth Davison Weatherley; Barry Greenberg; Gerassimos Filippatos; Elaine Unemori; Sam L. Teichman; Gad Cotter

doi:10.1159/000321416

Low Lymphocyte Ratio as a Novel Prognostic Factor in Acute Heart Failure: Results from the Pre-RELAX-AHF Study

Olga Milo-Cotter^*, John R. Teerlink, Marco Metra, G. Michael Felker, Piotr Ponikowski, Adriaan A. Voors, Christopher Edwards, Beth Davison Weatherley, Barry Greenberg, Gerassimos Filippatos, Elaine Unemori, Sam L. Teichman, Gad Cotter

^*Corresponding author for this work

Cardiovascular Centre (CVC)

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

Background: Previous studies have suggested that a lower lymphocyte ratio (Ly%) in the white blood cell (WBC) differential count is related to worse outcomes in patients with acute heart failure (AHF) and other cardiovascular disorders. Methods: In the Pre-RELAX-AHF study, 234 patients with AHF, systolic blood pressure >125 mm Hg and brain natriuretic peptide >= 350 pg/ml or equivalent were randomized to 1 of 4 intravenous doses of relaxin or placebo and followed up for 6 months following randomization. Complete blood count and differential were performed by a central laboratory at baseline and then daily to day 5 and on day 14. Results: The WBC count by itself was not associated with measures of disease severity or outcome, and patients with Ly% 13%, except for a higher baseline WBC count, elevated baseline glucose, older age and higher rates of peripheral vascular disease. However, patients with Ly%

Original language	English
Pages (from-to)	190-196
Number of pages	7
Journal	Cardiology
Volume	117
Issue number	3
DOIs	https://doi.org/10.1159/000321416
Publication status	Published - 2010

Keywords

White blood cells
Lymphocytes
Heart failure
COUNT
MORTALITY
TRANSPLANT
APOPTOSIS
SURVIVAL
DEATH
RISK

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Milo-Cotter, O., Teerlink, J. R., Metra, M., Felker, G. M., Ponikowski, P., Voors, A. A., Edwards, C., Weatherley, B. D., Greenberg, B., Filippatos, G., Unemori, E., Teichman, S. L., & Cotter, G. (2010). Low Lymphocyte Ratio as a Novel Prognostic Factor in Acute Heart Failure: Results from the Pre-RELAX-AHF Study. Cardiology, 117(3), 190-196. https://doi.org/10.1159/000321416

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title = "Low Lymphocyte Ratio as a Novel Prognostic Factor in Acute Heart Failure: Results from the Pre-RELAX-AHF Study",

abstract = "Background: Previous studies have suggested that a lower lymphocyte ratio (Ly%) in the white blood cell (WBC) differential count is related to worse outcomes in patients with acute heart failure (AHF) and other cardiovascular disorders. Methods: In the Pre-RELAX-AHF study, 234 patients with AHF, systolic blood pressure >125 mm Hg and brain natriuretic peptide >= 350 pg/ml or equivalent were randomized to 1 of 4 intravenous doses of relaxin or placebo and followed up for 6 months following randomization. Complete blood count and differential were performed by a central laboratory at baseline and then daily to day 5 and on day 14. Results: The WBC count by itself was not associated with measures of disease severity or outcome, and patients with Ly% 13%, except for a higher baseline WBC count, elevated baseline glucose, older age and higher rates of peripheral vascular disease. However, patients with Ly%",

keywords = "White blood cells, Lymphocytes, Heart failure, COUNT, MORTALITY, TRANSPLANT, APOPTOSIS, SURVIVAL, DEATH, RISK",

author = "Olga Milo-Cotter and Teerlink, {John R.} and Marco Metra and Felker, {G. Michael} and Piotr Ponikowski and Voors, {Adriaan A.} and Christopher Edwards and Weatherley, {Beth Davison} and Barry Greenberg and Gerassimos Filippatos and Elaine Unemori and Teichman, {Sam L.} and Gad Cotter",

year = "2010",

doi = "10.1159/000321416",

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T1 - Low Lymphocyte Ratio as a Novel Prognostic Factor in Acute Heart Failure

T2 - Results from the Pre-RELAX-AHF Study

AU - Milo-Cotter, Olga

AU - Teerlink, John R.

AU - Metra, Marco

AU - Felker, G. Michael

AU - Ponikowski, Piotr

AU - Voors, Adriaan A.

AU - Edwards, Christopher

AU - Weatherley, Beth Davison

AU - Greenberg, Barry

AU - Filippatos, Gerassimos

AU - Unemori, Elaine

AU - Teichman, Sam L.

AU - Cotter, Gad

PY - 2010

Y1 - 2010

N2 - Background: Previous studies have suggested that a lower lymphocyte ratio (Ly%) in the white blood cell (WBC) differential count is related to worse outcomes in patients with acute heart failure (AHF) and other cardiovascular disorders. Methods: In the Pre-RELAX-AHF study, 234 patients with AHF, systolic blood pressure >125 mm Hg and brain natriuretic peptide >= 350 pg/ml or equivalent were randomized to 1 of 4 intravenous doses of relaxin or placebo and followed up for 6 months following randomization. Complete blood count and differential were performed by a central laboratory at baseline and then daily to day 5 and on day 14. Results: The WBC count by itself was not associated with measures of disease severity or outcome, and patients with Ly% 13%, except for a higher baseline WBC count, elevated baseline glucose, older age and higher rates of peripheral vascular disease. However, patients with Ly%

AB - Background: Previous studies have suggested that a lower lymphocyte ratio (Ly%) in the white blood cell (WBC) differential count is related to worse outcomes in patients with acute heart failure (AHF) and other cardiovascular disorders. Methods: In the Pre-RELAX-AHF study, 234 patients with AHF, systolic blood pressure >125 mm Hg and brain natriuretic peptide >= 350 pg/ml or equivalent were randomized to 1 of 4 intravenous doses of relaxin or placebo and followed up for 6 months following randomization. Complete blood count and differential were performed by a central laboratory at baseline and then daily to day 5 and on day 14. Results: The WBC count by itself was not associated with measures of disease severity or outcome, and patients with Ly% 13%, except for a higher baseline WBC count, elevated baseline glucose, older age and higher rates of peripheral vascular disease. However, patients with Ly%

KW - White blood cells

KW - Lymphocytes

KW - Heart failure

KW - COUNT

KW - MORTALITY

KW - TRANSPLANT

KW - APOPTOSIS

KW - SURVIVAL

KW - DEATH

KW - RISK

U2 - 10.1159/000321416

DO - 10.1159/000321416

M3 - Article

SN - 0008-6312

VL - 117

SP - 190

EP - 196

JO - Cardiology

JF - Cardiology

IS - 3

ER -

Low Lymphocyte Ratio as a Novel Prognostic Factor in Acute Heart Failure: Results from the Pre-RELAX-AHF Study

Abstract

Keywords

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