Lead exposure biomarkers and mini-mental status exam scores in older men

RO Wright; SW Tsaih; J Schwartz; A Spiro; K McDonald; ST Weiss; H Hu

doi:10.1097/01.EDE0000081988.85964.db

Lead exposure biomarkers and mini-mental status exam scores in older men

RO Wright^*, SW Tsaih, J Schwartz, A Spiro, K McDonald, ST Weiss, H Hu

^*Corresponding author for this work

University of Groningen

Research output: Contribution to journal › Article › Academic › peer-review

94 Citations (Scopus)

Abstract

Background: Lead is neurotoxic; yet, whether cognitive decline in older persons is associated with lead exposure is unknown. We studied whether lead exposure biomarkers are associated with cognitive test scores, as well as the modifying effects of age on the lead-cognition relationship.

Methods: Lead exposure biomarkers and Mini-Mental Status Exam (MMSE) scores were measured among subjects in the Normative Aging Study. Multiple linear and logistic regression analyses were performed to examine the cross-sectional association of these 2 variables.

Results: We found an odds ratio (OR) of 2.1 for MMSE

Conclusions: Increased levels of lead in bone and blood are inversely associated with cognitive performance among older men. Lead exposure might accelerate age-associated cognitive decline.

Original language	English
Pages (from-to)	713-718
Number of pages	6
Journal	Epidemiology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1097/01.EDE0000081988.85964.db
Publication status	Published - Nov-2003

Keywords

lead
cognition
aging
Mini-Mental Status Examination
BLOOD LEAD
IN-VIVO
ALZHEIMERS-DISEASE
BONE LEAD
COGNITIVE FUNCTION
OXIDATIVE STRESS
CHRONIC TOXICITY
INORGANIC LEAD
ELDERLY MEN
POPULATION

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title = "Lead exposure biomarkers and mini-mental status exam scores in older men",

abstract = "Background: Lead is neurotoxic; yet, whether cognitive decline in older persons is associated with lead exposure is unknown. We studied whether lead exposure biomarkers are associated with cognitive test scores, as well as the modifying effects of age on the lead-cognition relationship.Methods: Lead exposure biomarkers and Mini-Mental Status Exam (MMSE) scores were measured among subjects in the Normative Aging Study. Multiple linear and logistic regression analyses were performed to examine the cross-sectional association of these 2 variables.Results: We found an odds ratio (OR) of 2.1 for MMSEConclusions: Increased levels of lead in bone and blood are inversely associated with cognitive performance among older men. Lead exposure might accelerate age-associated cognitive decline.",

keywords = "lead, cognition, aging, Mini-Mental Status Examination, BLOOD LEAD, IN-VIVO, ALZHEIMERS-DISEASE, BONE LEAD, COGNITIVE FUNCTION, OXIDATIVE STRESS, CHRONIC TOXICITY, INORGANIC LEAD, ELDERLY MEN, POPULATION",

author = "RO Wright and SW Tsaih and J Schwartz and A Spiro and K McDonald and ST Weiss and H Hu",

year = "2003",

month = nov,

doi = "10.1097/01.EDE0000081988.85964.db",

language = "English",

volume = "14",

pages = "713--718",

journal = "Epidemiology",

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TY - JOUR

T1 - Lead exposure biomarkers and mini-mental status exam scores in older men

AU - Wright, RO

AU - Tsaih, SW

AU - Schwartz, J

AU - Spiro, A

AU - McDonald, K

AU - Weiss, ST

AU - Hu, H

PY - 2003/11

Y1 - 2003/11

N2 - Background: Lead is neurotoxic; yet, whether cognitive decline in older persons is associated with lead exposure is unknown. We studied whether lead exposure biomarkers are associated with cognitive test scores, as well as the modifying effects of age on the lead-cognition relationship.Methods: Lead exposure biomarkers and Mini-Mental Status Exam (MMSE) scores were measured among subjects in the Normative Aging Study. Multiple linear and logistic regression analyses were performed to examine the cross-sectional association of these 2 variables.Results: We found an odds ratio (OR) of 2.1 for MMSEConclusions: Increased levels of lead in bone and blood are inversely associated with cognitive performance among older men. Lead exposure might accelerate age-associated cognitive decline.

AB - Background: Lead is neurotoxic; yet, whether cognitive decline in older persons is associated with lead exposure is unknown. We studied whether lead exposure biomarkers are associated with cognitive test scores, as well as the modifying effects of age on the lead-cognition relationship.Methods: Lead exposure biomarkers and Mini-Mental Status Exam (MMSE) scores were measured among subjects in the Normative Aging Study. Multiple linear and logistic regression analyses were performed to examine the cross-sectional association of these 2 variables.Results: We found an odds ratio (OR) of 2.1 for MMSEConclusions: Increased levels of lead in bone and blood are inversely associated with cognitive performance among older men. Lead exposure might accelerate age-associated cognitive decline.

KW - lead

KW - cognition

KW - aging

KW - Mini-Mental Status Examination

KW - BLOOD LEAD

KW - IN-VIVO

KW - ALZHEIMERS-DISEASE

KW - BONE LEAD

KW - COGNITIVE FUNCTION

KW - OXIDATIVE STRESS

KW - CHRONIC TOXICITY

KW - INORGANIC LEAD

KW - ELDERLY MEN

KW - POPULATION

U2 - 10.1097/01.EDE0000081988.85964.db

DO - 10.1097/01.EDE0000081988.85964.db

M3 - Article

SN - 1044-3983

VL - 14

SP - 713

EP - 718

JO - Epidemiology

JF - Epidemiology

IS - 6

ER -

Lead exposure biomarkers and mini-mental status exam scores in older men

Abstract

Keywords

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