Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation

W. N. Nijboer; T. A. Schuurs; J. Damman; H. van Goor; V. S. Vaidya; J. J. Homan van der Heide; H. G. D. Leuvenink; J. V. Bonventre; R. J. Ploeg

doi:10.1111/j.1600-6143.2009.02713.x

Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation

W. N. Nijboer^*, T. A. Schuurs, J. Damman, H. van Goor, V. S. Vaidya, J. J. Homan van der Heide, H. G. D. Leuvenink, J. V. Bonventre, R. J. Ploeg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

36 Citations (Scopus)

Abstract

In rat kidney, real-time PCR revealed a 46-fold Kim-1 gene upregulation after 4 h of brain death. In situ hybridization showed proximal tubular Kim-1 localization, which was confirmed by immunohistochemistry. Also, Luminex assay showed a 6.6-fold Kim-1 rise in urine after 4 h of brain death. In human donors, 2.5-fold kidney injury molecule-1 (KIM-1) gene upregulation and 2-fold higher urine levels were found in donation after brain death (DBD) donors compared to living kidney donors. Multiple regression analysis showed that urinary KIM-1 at brain death diagnosis was a positive predictor of recipient serum creatinine, 14 days (p <0.001) and 1 year (p <0.05) after kidney transplantation.

In conclusion, we think that Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage.

Original language	English
Pages (from-to)	1752-1759
Number of pages	8
Journal	American Journal of Transplantation
Volume	9
Issue number	8
DOIs	https://doi.org/10.1111/j.1600-6143.2009.02713.x
Publication status	Published - Aug-2009

Keywords

Brain death
donor evaluation
kidney
KIM-1
RENAL-TRANSPLANTATION
MULTIVARIATE-ANALYSIS
GRAFT FUNCTION
ACTIVATION
EXPRESSION
BIOMARKER
SURVIVAL
DURATION
TISSUE

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Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation
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Nijboer, W. N., Schuurs, T. A., Damman, J., van Goor, H., Vaidya, V. S., van der Heide, J. J. H., Leuvenink, H. G. D., Bonventre, J. V., & Ploeg, R. J. (2009). Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation. American Journal of Transplantation, 9(8), 1752-1759. https://doi.org/10.1111/j.1600-6143.2009.02713.x

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title = "Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation",

abstract = "In rat kidney, real-time PCR revealed a 46-fold Kim-1 gene upregulation after 4 h of brain death. In situ hybridization showed proximal tubular Kim-1 localization, which was confirmed by immunohistochemistry. Also, Luminex assay showed a 6.6-fold Kim-1 rise in urine after 4 h of brain death. In human donors, 2.5-fold kidney injury molecule-1 (KIM-1) gene upregulation and 2-fold higher urine levels were found in donation after brain death (DBD) donors compared to living kidney donors. Multiple regression analysis showed that urinary KIM-1 at brain death diagnosis was a positive predictor of recipient serum creatinine, 14 days (p <0.001) and 1 year (p <0.05) after kidney transplantation.In conclusion, we think that Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage.",

keywords = "Brain death, donor evaluation, kidney, KIM-1, RENAL-TRANSPLANTATION, MULTIVARIATE-ANALYSIS, GRAFT FUNCTION, ACTIVATION, EXPRESSION, BIOMARKER, SURVIVAL, DURATION, TISSUE",

author = "Nijboer, {W. N.} and Schuurs, {T. A.} and J. Damman and {van Goor}, H. and Vaidya, {V. S.} and {van der Heide}, {J. J. Homan} and Leuvenink, {H. G. D.} and Bonventre, {J. V.} and Ploeg, {R. J.}",

year = "2009",

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doi = "10.1111/j.1600-6143.2009.02713.x",

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Nijboer, WN, Schuurs, TA, Damman, J, van Goor, H, Vaidya, VS, van der Heide, JJH, Leuvenink, HGD, Bonventre, JV & Ploeg, RJ 2009, 'Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation', American Journal of Transplantation, vol. 9, no. 8, pp. 1752-1759. https://doi.org/10.1111/j.1600-6143.2009.02713.x

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T1 - Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation

AU - Nijboer, W. N.

AU - Schuurs, T. A.

AU - Damman, J.

AU - van Goor, H.

AU - Vaidya, V. S.

AU - van der Heide, J. J. Homan

AU - Leuvenink, H. G. D.

AU - Bonventre, J. V.

AU - Ploeg, R. J.

PY - 2009/8

Y1 - 2009/8

N2 - In rat kidney, real-time PCR revealed a 46-fold Kim-1 gene upregulation after 4 h of brain death. In situ hybridization showed proximal tubular Kim-1 localization, which was confirmed by immunohistochemistry. Also, Luminex assay showed a 6.6-fold Kim-1 rise in urine after 4 h of brain death. In human donors, 2.5-fold kidney injury molecule-1 (KIM-1) gene upregulation and 2-fold higher urine levels were found in donation after brain death (DBD) donors compared to living kidney donors. Multiple regression analysis showed that urinary KIM-1 at brain death diagnosis was a positive predictor of recipient serum creatinine, 14 days (p <0.001) and 1 year (p <0.05) after kidney transplantation.In conclusion, we think that Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage.

AB - In rat kidney, real-time PCR revealed a 46-fold Kim-1 gene upregulation after 4 h of brain death. In situ hybridization showed proximal tubular Kim-1 localization, which was confirmed by immunohistochemistry. Also, Luminex assay showed a 6.6-fold Kim-1 rise in urine after 4 h of brain death. In human donors, 2.5-fold kidney injury molecule-1 (KIM-1) gene upregulation and 2-fold higher urine levels were found in donation after brain death (DBD) donors compared to living kidney donors. Multiple regression analysis showed that urinary KIM-1 at brain death diagnosis was a positive predictor of recipient serum creatinine, 14 days (p <0.001) and 1 year (p <0.05) after kidney transplantation.In conclusion, we think that Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage.

KW - Brain death

KW - donor evaluation

KW - kidney

KW - KIM-1

KW - RENAL-TRANSPLANTATION

KW - MULTIVARIATE-ANALYSIS

KW - GRAFT FUNCTION

KW - ACTIVATION

KW - EXPRESSION

KW - BIOMARKER

KW - SURVIVAL

KW - DURATION

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DO - 10.1111/j.1600-6143.2009.02713.x

M3 - Article

SN - 1600-6135

VL - 9

SP - 1752

EP - 1759

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 8

ER -

Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation

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