TY - JOUR
T1 - Frequency of CDH1 germline variants and contribution of dietary habits in early age onset gastric cancer patients in Brazil
AU - Santa Cruz Guindalini, Rodrigo
AU - Visontai Cormedi, Marina Candido
AU - Maistro, Simone
AU - Pasini, Fatima Solange
AU - Abduch Adas Branas, Priscila Cristina
AU - dos Santos, Liliane
AU - de Lima Pereira, Glaucia Fernanda
AU - de Bock, Geertruida Hendrika
AU - Saccaro, Daniela Marques
AU - Hirata Katayama, Maria Lucia
AU - Faraj, Sheila Friedrich
AU - Safatle-Ribeiro, Adriana
AU - Ribeiro Junior, Ulysses
AU - Estevez Diz, Maria Del Pilar
AU - Ribeiro Chaves de Gouvea, Ana Carolina
AU - Chammas, Roger
AU - Azevedo Koike Folgueira, Maria Aparecida
PY - 2019/9
Y1 - 2019/9
N2 - Introduction The contribution of CDH1 germline variants to gastric cancer burden among young adults is unknown in Brazil. We aimed to evaluate the frequency of CDH1 germline variants and the diet/lifestyle habits in early age onset gastric cancer (EOGC, A, c.387G>T, c.1676G>A, and c.1806C>A. The MLPA results revealed no rearrangements and CDH1 transcription analysis for variants of interest were inconclusive. EOGC patients had a higher red (OR:2.6, 95%CI:1.4-4.9) and processed (OR:3.1, 95%CI:1.6-6.0) meat intake and higher fruit consumption (OR:0.4, 95%IC:0.3-0.7) compared to eating habits of the Brazilian population. Conclusions No unequivocal pathogenic germline CDH1 variants were identified in Brazilian EOGC patients. Dietary habits may be associated with the EOGC development.
AB - Introduction The contribution of CDH1 germline variants to gastric cancer burden among young adults is unknown in Brazil. We aimed to evaluate the frequency of CDH1 germline variants and the diet/lifestyle habits in early age onset gastric cancer (EOGC, A, c.387G>T, c.1676G>A, and c.1806C>A. The MLPA results revealed no rearrangements and CDH1 transcription analysis for variants of interest were inconclusive. EOGC patients had a higher red (OR:2.6, 95%CI:1.4-4.9) and processed (OR:3.1, 95%CI:1.6-6.0) meat intake and higher fruit consumption (OR:0.4, 95%IC:0.3-0.7) compared to eating habits of the Brazilian population. Conclusions No unequivocal pathogenic germline CDH1 variants were identified in Brazilian EOGC patients. Dietary habits may be associated with the EOGC development.
KW - CDH1
KW - Diet
KW - Hereditary diffuse gastric cancer
KW - E-cadherin
KW - Risk factors
KW - E-CADHERIN GENE
KW - CELL-CELL ADHESION
KW - MUTATIONS
KW - GUIDELINES
KW - INACTIVATION
KW - FAMILIES
U2 - 10.1007/s10120-019-00945-9
DO - 10.1007/s10120-019-00945-9
M3 - Article
SN - 1436-3291
VL - 22
SP - 920
EP - 931
JO - Gastric cancer
JF - Gastric cancer
IS - 5
ER -