Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

P Nieboer; Elisabeth G. E. de Vries; Nanno Mulder; S Rodenhuis; M Bontenbal; E van der Wall; Q G van Hoesel; W M Smit; P Hupperets; E E Voest; M A Nooij; H M Boezen; W T A van der Graaf

doi:10.1038/bmt.2008.195

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

P Nieboer, Elisabeth G. E. de Vries, Nanno Mulder, S Rodenhuis, M Bontenbal, E van der Wall, Q G van Hoesel, W M Smit, P Hupperets, E E Voest, M A Nooij, H M Boezen, W T A van der Graaf

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia >10 days (P=0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P= <0.01), and use of total parenteral nutrition (TPN, P=0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.

Original language	English
Pages (from-to)	475-481
Number of pages	7
Journal	Bone marrow transplantation
Volume	42
Issue number	7
DOIs	https://doi.org/10.1038/bmt.2008.195
Publication status	Published - Oct-2008

Keywords

central venous catheter
infections
high-dose chemotherapy
SCT
breast cancer
CENTRAL VENOUS CATHETERS
STEM-CELL TRANSPLANTATION
BLOOD-STREAM INFECTION
TOTAL PARENTERAL-NUTRITION
DOUBLE-BLIND TRIAL
RANDOMIZED-TRIAL
ACCESS DEVICES
ONCOLOGY PATIENTS
PREVENTION
SUPPORT

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Nieboer, P., de Vries, E. G. E., Mulder, N., Rodenhuis, S., Bontenbal, M., van der Wall, E., van Hoesel, Q. G., Smit, W. M., Hupperets, P., Voest, E. E., Nooij, M. A., Boezen, H. M., & van der Graaf, W. T. A. (2008). Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients. Bone marrow transplantation, 42(7), 475-481. https://doi.org/10.1038/bmt.2008.195

@article{12267e82b1d2465dae96fb16a99df118,

title = "Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients",

abstract = "Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia >10 days (P=0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P= <0.01), and use of total parenteral nutrition (TPN, P=0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.",

keywords = "central venous catheter, infections, high-dose chemotherapy, SCT, breast cancer, CENTRAL VENOUS CATHETERS, STEM-CELL TRANSPLANTATION, BLOOD-STREAM INFECTION, TOTAL PARENTERAL-NUTRITION, DOUBLE-BLIND TRIAL, RANDOMIZED-TRIAL, ACCESS DEVICES, ONCOLOGY PATIENTS, PREVENTION, SUPPORT",

author = "P Nieboer and {de Vries}, {Elisabeth G. E.} and Nanno Mulder and S Rodenhuis and M Bontenbal and {van der Wall}, E and {van Hoesel}, {Q G} and Smit, {W M} and P Hupperets and Voest, {E E} and Nooij, {M A} and Boezen, {H M} and {van der Graaf}, {W T A}",

year = "2008",

month = oct,

doi = "10.1038/bmt.2008.195",

language = "English",

volume = "42",

pages = "475--481",

journal = "Bone marrow transplantation",

issn = "0268-3369",

publisher = "Nature Publishing Group",

number = "7",

}

Nieboer, P, de Vries, EGE, Mulder, N, Rodenhuis, S, Bontenbal, M, van der Wall, E, van Hoesel, QG, Smit, WM, Hupperets, P, Voest, EE, Nooij, MA, Boezen, HM & van der Graaf, WTA 2008, 'Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients', Bone marrow transplantation, vol. 42, no. 7, pp. 475-481. https://doi.org/10.1038/bmt.2008.195

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients. / Nieboer, P; de Vries, Elisabeth G. E.; Mulder, Nanno et al.
In: Bone marrow transplantation, Vol. 42, No. 7, 10.2008, p. 475-481.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

AU - Nieboer, P

AU - de Vries, Elisabeth G. E.

AU - Mulder, Nanno

AU - Rodenhuis, S

AU - Bontenbal, M

AU - van der Wall, E

AU - van Hoesel, Q G

AU - Smit, W M

AU - Hupperets, P

AU - Voest, E E

AU - Nooij, M A

AU - Boezen, H M

AU - van der Graaf, W T A

PY - 2008/10

Y1 - 2008/10

N2 - Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia >10 days (P=0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P= <0.01), and use of total parenteral nutrition (TPN, P=0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.

AB - Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. Median catheter dwell time was 25 days (range 1-141). Catheter-related infections were seen in 28.3% of patients (11 infections per 1000 catheter-days). Coagulase-negative staphylococci were found in 104 of 186 positive blood cultures (56%). No systemic fungal infections occurred. Cox regression analysis showed that duration of neutropenia >10 days (P=0.04), using the catheter for both stem-cell apheresis and high-dose chemotherapy (P= <0.01), and use of total parenteral nutrition (TPN, P=0.04) were predictive for catheter-related infections. In conclusion, a high incidence of catheter-related infections after high-dose chemotherapy was seen related to duration of neutropenia, use of the catheter for both stem-cell apheresis and high-dose chemotherapy, and use of TPN. Selective use and choice of catheters could lead to a substantial reduction of catheter-related infectious complications.

KW - central venous catheter

KW - infections

KW - high-dose chemotherapy

KW - SCT

KW - breast cancer

KW - CENTRAL VENOUS CATHETERS

KW - STEM-CELL TRANSPLANTATION

KW - BLOOD-STREAM INFECTION

KW - TOTAL PARENTERAL-NUTRITION

KW - DOUBLE-BLIND TRIAL

KW - RANDOMIZED-TRIAL

KW - ACCESS DEVICES

KW - ONCOLOGY PATIENTS

KW - PREVENTION

KW - SUPPORT

U2 - 10.1038/bmt.2008.195

DO - 10.1038/bmt.2008.195

M3 - Article

C2 - 18622420

SN - 0268-3369

VL - 42

SP - 475

EP - 481

JO - Bone marrow transplantation

JF - Bone marrow transplantation

IS - 7

ER -

Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

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Keywords

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