Ethylene, an early marker of systemic inflammation in humans

Laurent M. Paardekooper; Geert van den Bogaart; Matthijs Kox; Ilse Dingjan; Anne H. Neerincx; Maura B. Bendix; Martin ter Beest; Frans J. M. Harren; Terence Risby; Peter Pickkers; Nandor Marczin; Simona M. Cristescu

doi:10.1038/s41598-017-05930-9

Ethylene, an early marker of systemic inflammation in humans

Laurent M. Paardekooper, Geert van den Bogaart, Matthijs Kox, Ilse Dingjan, Anne H. Neerincx, Maura B. Bendix, Martin ter Beest, Frans J. M. Harren, Terence Risby, Peter Pickkers, Nandor Marczin, Simona M. Cristescu^*

^*Corresponding author for this work

Molecular Immunology & Microbiology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.

Original language	English
Article number	6889
Number of pages	10
Journal	Scientific Reports
Volume	7
DOIs	https://doi.org/10.1038/s41598-017-05930-9
Publication status	Published - 31-Jul-2017

Keywords

LASER PHOTOACOUSTIC DETECTION
IN-VIVO
LIPID-PEROXIDATION
CROSS-PRESENTATION
DENDRITIC CELLS
IMMUNE-RESPONSE
HUMAN SKIN
OXIDASE
PLANTS
MECHANISM

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@article{14b79cf8a232437b9a4ad9ac011b51d0,

title = "Ethylene, an early marker of systemic inflammation in humans",

abstract = "Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.",

keywords = "LASER PHOTOACOUSTIC DETECTION, IN-VIVO, LIPID-PEROXIDATION, CROSS-PRESENTATION, DENDRITIC CELLS, IMMUNE-RESPONSE, HUMAN SKIN, OXIDASE, PLANTS, MECHANISM",

author = "Paardekooper, {Laurent M.} and {van den Bogaart}, Geert and Matthijs Kox and Ilse Dingjan and Neerincx, {Anne H.} and Bendix, {Maura B.} and {ter Beest}, Martin and Harren, {Frans J. M.} and Terence Risby and Peter Pickkers and Nandor Marczin and Cristescu, {Simona M.}",

year = "2017",

month = jul,

day = "31",

doi = "10.1038/s41598-017-05930-9",

language = "English",

volume = "7",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Ethylene, an early marker of systemic inflammation in humans

AU - Paardekooper, Laurent M.

AU - van den Bogaart, Geert

AU - Kox, Matthijs

AU - Dingjan, Ilse

AU - Neerincx, Anne H.

AU - Bendix, Maura B.

AU - ter Beest, Martin

AU - Harren, Frans J. M.

AU - Risby, Terence

AU - Pickkers, Peter

AU - Marczin, Nandor

AU - Cristescu, Simona M.

PY - 2017/7/31

Y1 - 2017/7/31

N2 - Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.

AB - Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.

KW - LASER PHOTOACOUSTIC DETECTION

KW - IN-VIVO

KW - LIPID-PEROXIDATION

KW - CROSS-PRESENTATION

KW - DENDRITIC CELLS

KW - IMMUNE-RESPONSE

KW - HUMAN SKIN

KW - OXIDASE

KW - PLANTS

KW - MECHANISM

U2 - 10.1038/s41598-017-05930-9

DO - 10.1038/s41598-017-05930-9

M3 - Article

SN - 2045-2322

VL - 7

JO - Scientific Reports

JF - Scientific Reports

M1 - 6889

ER -

Ethylene, an early marker of systemic inflammation in humans

Abstract

Keywords

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