Controlled Delivery of Methotrexate from Channel-Protein Containing Liposomes

M. van Deemter; J. Šmisterová; G. van der Schaaf; W. Meijberg; G. Robillard

Controlled Delivery of Methotrexate from Channel-Protein Containing Liposomes

M. van Deemter, J. Šmisterová, G. van der Schaaf, W. Meijberg, G. Robillard

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Abstract

The goal of this study is to develop a controlled methotrexate delivery system that releases its content by a target specific stimulus. To accomplish this, both methotrexate and an engineered channel protein (MscL) were incorporated into DOPC/CH/DSPE-PEG liposomes, providing a controlled drug delivery system. Reconstitution and encapsulation methods were optimized in order to ensure optimal channel gating activity and high drug:lipid ratio. At the optimal conditions, a 95% release of MTX could be reached.

Original language	English
Pages (from-to)	342-343
Number of pages	2
Journal	Journal of Controlled Release
Volume	101
Issue number	1-3
Publication status	Published - 2005

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title = "Controlled Delivery of Methotrexate from Channel-Protein Containing Liposomes",

abstract = "The goal of this study is to develop a controlled methotrexate delivery system that releases its content by a target specific stimulus. To accomplish this, both methotrexate and an engineered channel protein (MscL) were incorporated into DOPC/CH/DSPE-PEG liposomes, providing a controlled drug delivery system. Reconstitution and encapsulation methods were optimized in order to ensure optimal channel gating activity and high drug:lipid ratio. At the optimal conditions, a 95% release of MTX could be reached.",

author = "Deemter, {M. van} and J. {\v S}misterov{\'a} and Schaaf, {G. van der} and W. Meijberg and G. Robillard",

note = "Relation: http://www.rug.nl/gbb/ date_submitted:2009 Rights: University of Groningen. Groningen Biomolecular Sciences and Biotechnology Institute",

year = "2005",

language = "English",

volume = "101",

pages = "342--343",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier Bedrijfsinformatie b.v.",

number = "1-3",

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TY - JOUR

T1 - Controlled Delivery of Methotrexate from Channel-Protein Containing Liposomes

AU - Deemter, M. van

AU - Šmisterová, J.

AU - Schaaf, G. van der

AU - Meijberg, W.

AU - Robillard, G.

N1 - Relation: http://www.rug.nl/gbb/ date_submitted:2009 Rights: University of Groningen. Groningen Biomolecular Sciences and Biotechnology Institute

PY - 2005

Y1 - 2005

N2 - The goal of this study is to develop a controlled methotrexate delivery system that releases its content by a target specific stimulus. To accomplish this, both methotrexate and an engineered channel protein (MscL) were incorporated into DOPC/CH/DSPE-PEG liposomes, providing a controlled drug delivery system. Reconstitution and encapsulation methods were optimized in order to ensure optimal channel gating activity and high drug:lipid ratio. At the optimal conditions, a 95% release of MTX could be reached.

AB - The goal of this study is to develop a controlled methotrexate delivery system that releases its content by a target specific stimulus. To accomplish this, both methotrexate and an engineered channel protein (MscL) were incorporated into DOPC/CH/DSPE-PEG liposomes, providing a controlled drug delivery system. Reconstitution and encapsulation methods were optimized in order to ensure optimal channel gating activity and high drug:lipid ratio. At the optimal conditions, a 95% release of MTX could be reached.

M3 - Article

SN - 0168-3659

VL - 101

SP - 342

EP - 343

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 1-3

ER -

Controlled Delivery of Methotrexate from Channel-Protein Containing Liposomes

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