Clinical use of the determination of serotonin in whole blood

HP Kremer; J G Goekoop; G M Van Kempen

Clinical use of the determination of serotonin in whole blood

HP Kremer, J G Goekoop, G M Van Kempen

Molecular Neuroscience and Ageing Research (MOLAR)

Research output: Contribution to journal › Article › Academic › peer-review

60 Citations (Scopus)

Abstract

Whole blood serotonin (5-hydroxytryptamine, 5-HT) was assayed, and factors possibly influencing 5-HT content were investigated in healthy controls. No significant circadian rhythm or effect of dexamethasone or meals was observed. After use of fluvoxamine, a specific 5-HT reuptake inhibitor, the whole-blood 5-HT concentration of patients was strongly reduced. After treatment with tranylcypromine, an unspecific monoamine oxidase inhibitor (MAOI), the 5-HT content was increased. Determination of whole blood 5-HT in patients treated with fluvoxamine presents a measure of drug compliance. Furthermore, the method may have clinical potential for finding an adequate dose when a 5-HT reuptake inhibitor or an MAOI is used.

Original language	English
Pages (from-to)	83-7
Number of pages	5
Journal	Journal of Clinical Psychopharmacology
Volume	10
Issue number	2
Publication status	Published - Apr-1990

Keywords

Adult
Circadian Rhythm
Depressive Disorder
Dexamethasone
Fluvoxamine
Humans
Male
Oximes
Serotonin
Tranylcypromine

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Kremer, HP., Goekoop, J. G., & Van Kempen, G. M. (1990). Clinical use of the determination of serotonin in whole blood. Journal of Clinical Psychopharmacology, 10(2), 83-7. http://ovidsp.tx.ovid.com/sp-3.18.0b/ovidweb.cgi?WebLinkFrameset=1&S=BODMFPLFDDDDMGJDNCJKDDLBDDLIAA00&returnUrl=ovidweb.cgi%3fMain%2bSearch%2bPage%3d1%26S%3dBODMFPLFDDDDMGJDNCJKDDLBDDLIAA00&directlink=http%3a%2f%2fgraphics.tx.ovid.com%2fovftpdfs%2fFPDDNCLBDDJDDD00%2ffs046%2fovft%2flive%2fgv023%2f00004714%2f00004714-199004000-00002.pdf&filename=Clinical+Use+of+the+Determination+of+Serotonin+in+Whole+Blood.&navigation_links=NavLinks.S.sh.22.1&link_from=S.sh.22%7c1&pdf_key=FPDDNCLBDDJDDD00&pdf_index=/fs046/ovft/live/gv023/00004714/00004714-199004000-00002&D=ovft&link_set=S.sh.22|1|sl_10|resultSet|S.sh.22.23|0

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title = "Clinical use of the determination of serotonin in whole blood",

abstract = "Whole blood serotonin (5-hydroxytryptamine, 5-HT) was assayed, and factors possibly influencing 5-HT content were investigated in healthy controls. No significant circadian rhythm or effect of dexamethasone or meals was observed. After use of fluvoxamine, a specific 5-HT reuptake inhibitor, the whole-blood 5-HT concentration of patients was strongly reduced. After treatment with tranylcypromine, an unspecific monoamine oxidase inhibitor (MAOI), the 5-HT content was increased. Determination of whole blood 5-HT in patients treated with fluvoxamine presents a measure of drug compliance. Furthermore, the method may have clinical potential for finding an adequate dose when a 5-HT reuptake inhibitor or an MAOI is used.",

keywords = "Adult, Circadian Rhythm, Depressive Disorder, Dexamethasone, Fluvoxamine, Humans, Male, Oximes, Serotonin, Tranylcypromine",

author = "HP Kremer and Goekoop, {J G} and {Van Kempen}, {G M}",

year = "1990",

month = apr,

language = "English",

volume = "10",

pages = "83--7",

journal = "Journal of Clinical Psychopharmacology",

issn = "0271-0749",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "2",

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Kremer, HP, Goekoop, JG & Van Kempen, GM 1990, 'Clinical use of the determination of serotonin in whole blood', Journal of Clinical Psychopharmacology, vol. 10, no. 2, pp. 83-7. <http://ovidsp.tx.ovid.com/sp-3.18.0b/ovidweb.cgi?WebLinkFrameset=1&S=BODMFPLFDDDDMGJDNCJKDDLBDDLIAA00&returnUrl=ovidweb.cgi%3fMain%2bSearch%2bPage%3d1%26S%3dBODMFPLFDDDDMGJDNCJKDDLBDDLIAA00&directlink=http%3a%2f%2fgraphics.tx.ovid.com%2fovftpdfs%2fFPDDNCLBDDJDDD00%2ffs046%2fovft%2flive%2fgv023%2f00004714%2f00004714-199004000-00002.pdf&filename=Clinical+Use+of+the+Determination+of+Serotonin+in+Whole+Blood.&navigation_links=NavLinks.S.sh.22.1&link_from=S.sh.22%7c1&pdf_key=FPDDNCLBDDJDDD00&pdf_index=/fs046/ovft/live/gv023/00004714/00004714-199004000-00002&D=ovft&link_set=S.sh.22|1|sl_10|resultSet|S.sh.22.23|0>

TY - JOUR

T1 - Clinical use of the determination of serotonin in whole blood

AU - Kremer, HP

AU - Goekoop, J G

AU - Van Kempen, G M

PY - 1990/4

Y1 - 1990/4

N2 - Whole blood serotonin (5-hydroxytryptamine, 5-HT) was assayed, and factors possibly influencing 5-HT content were investigated in healthy controls. No significant circadian rhythm or effect of dexamethasone or meals was observed. After use of fluvoxamine, a specific 5-HT reuptake inhibitor, the whole-blood 5-HT concentration of patients was strongly reduced. After treatment with tranylcypromine, an unspecific monoamine oxidase inhibitor (MAOI), the 5-HT content was increased. Determination of whole blood 5-HT in patients treated with fluvoxamine presents a measure of drug compliance. Furthermore, the method may have clinical potential for finding an adequate dose when a 5-HT reuptake inhibitor or an MAOI is used.

AB - Whole blood serotonin (5-hydroxytryptamine, 5-HT) was assayed, and factors possibly influencing 5-HT content were investigated in healthy controls. No significant circadian rhythm or effect of dexamethasone or meals was observed. After use of fluvoxamine, a specific 5-HT reuptake inhibitor, the whole-blood 5-HT concentration of patients was strongly reduced. After treatment with tranylcypromine, an unspecific monoamine oxidase inhibitor (MAOI), the 5-HT content was increased. Determination of whole blood 5-HT in patients treated with fluvoxamine presents a measure of drug compliance. Furthermore, the method may have clinical potential for finding an adequate dose when a 5-HT reuptake inhibitor or an MAOI is used.

KW - Adult

KW - Circadian Rhythm

KW - Depressive Disorder

KW - Dexamethasone

KW - Fluvoxamine

KW - Humans

KW - Male

KW - Oximes

KW - Serotonin

KW - Tranylcypromine

M3 - Article

C2 - 2111336

SN - 0271-0749

VL - 10

SP - 83

EP - 87

JO - Journal of Clinical Psychopharmacology

JF - Journal of Clinical Psychopharmacology

IS - 2

ER -

Clinical use of the determination of serotonin in whole blood

Abstract

Keywords

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