Abstract
OBJECTIVE: To assess the clinical, immunological and virological response and the emergence of resistance towards antiretroviral therapy (ART) in a cohort of HIV-2-infected patients.
DESIGN: Observational study.
PATIENTS: HIV-2-infected patients residing in the Netherlands.
RESULTS: From 1995 to 2001 seven patients failed various ART regimens. The resistance mutations were analysed retrospectively. Development of mutations proved to be similar to that observed in HIV-1-infected patients, with the exception of a higher occurrence of the Q151M mutation within the reverse transcriptase gene. In a prospective study, comprising 13 consecutive naive HIV-2-infected patients, all patients achieved plasma HIV-2-RNA suppression below the detection limit (500 copies/ml). The antiretroviral regimen consisted of two nucleoside reverse transcriptase inhibitors (NRTIs) and indinavir, with a boosting dose of ritonavir; the median follow-up was 91 weeks. Two patients experienced a temporary virological rebound, while at the same time therapeutic drug monitoring showed sub-therapeutic plasma levels of indinavir.
CONCLUSION: Sustained viral suppression in HIV-2-infected patients can be achieved using an antiretroviral regimen of two NRTIs and boosted indinavir or lopinavir.
| Original language | English |
|---|---|
| Pages (from-to) | S55-61 |
| Number of pages | 7 |
| Journal | Aids |
| Volume | 17 Suppl 3 |
| Publication status | Published - Jul-2003 |
| Externally published | Yes |
Keywords
- Adult
- Aged
- Anti-HIV Agents
- CD4 Lymphocyte Count
- Drug Resistance, Viral
- Drug Therapy, Combination
- Female
- Genes, Viral
- Genotype
- HIV Infections
- HIV Protease Inhibitors
- HIV-2
- Humans
- Male
- Middle Aged
- Mutation
- Prospective Studies
- Retrospective Studies
- Reverse Transcriptase Inhibitors
- Salvage Therapy
- Treatment Failure
- Viral Load