Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study

Dominique S. Michaud; Gerald Bove; Valentina Gallo; Brigitte Schlehofer; Anne Tjonneland; Anja Olsen; Kim Overvad; Christina C. Dahm; Brigit Teucher; Heiner Boeing; Annika Steffen; Antonia Trichopoulou; Christina Bamia; Andreas Kyrozis; Carlotta Sacerdote; Claudia Agnoli; Domenico Palli; Rosario Tumino; Amalia Mattiello; H. Bas Bueno-de-Mesquita; Petra H. M. Peeters; Anne M. May; Aurelio Barricarte; Maria-Dolores Chirlaque; Miren Dorronsoro; Maria Jose Sanchez; Laudina Rodriguez; Eric J. Duell; Goran Hallmans; Beatrice S. Melin; Jonas Manjer; Signe Borgquist; Kay-Tee Khaw; Nick Wareham; Naomi E. Allen; Ruth C. Travis; Isabelle Romieu; Paolo Vineis; Elio Riboli

doi:10.1158/1940-6207.CAPR-11-0014

Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study

Dominique S. Michaud^*, Gerald Bove, Valentina Gallo, Brigitte Schlehofer, Anne Tjonneland, Anja Olsen, Kim Overvad, Christina C. Dahm, Brigit Teucher, Heiner Boeing, Annika Steffen, Antonia Trichopoulou, Christina Bamia, Andreas Kyrozis, Carlotta Sacerdote, Claudia Agnoli, Domenico Palli, Rosario Tumino, Amalia Mattiello, H. Bas Bueno-de-MesquitaPetra H. M. Peeters, Anne M. May, Aurelio Barricarte, Maria-Dolores Chirlaque, Miren Dorronsoro, Maria Jose Sanchez, Laudina Rodriguez, Eric J. Duell, Goran Hallmans, Beatrice S. Melin, Jonas Manjer, Signe Borgquist, Kay-Tee Khaw, Nick Wareham, Naomi E. Allen, Ruth C. Travis, Isabelle Romieu, Paolo Vineis, Elio Riboli

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

56 Citations (Scopus)

Abstract

Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the analysis for measures of body fat, height, and physical activity among 380,775 participants. All analyses were conducted using Cox proportional hazards model and controlling for age, sex, country, and education. A 71% increase in risk of meningioma was observed among men and women in the top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73, P-trend = 0.01). A positive association was also observed for BMI and meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI >= 30 compared with a BMI of 20-24.9, P-trend = 0.05). An association with height and meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10 cm increase). In contrast, no associations were observed for height and different measures of body fat and risk of glioma. Physical activity was not related to either type of brain tumors. Results from this study support an increase in risk of meningioma with higher body fatness among both men and women. No association was observed between anthropometric measures and risk of glioma. Cancer Prev Res; 4(9); 1385-92. (C) 2011 AACR.

Original language	English
Pages (from-to)	1385-1392
Number of pages	8
Journal	Cancer Prevention Research
Volume	4
Issue number	9
DOIs	https://doi.org/10.1158/1940-6207.CAPR-11-0014
Publication status	Published - Sept-2011
Externally published	Yes

Keywords

BRAIN-TUMORS
CANCER
HEIGHT
WEIGHT
GROWTH
OVERWEIGHT
MORTALITY
VALIDITY
OBESITY
LIFE

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Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study
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Michaud, D. S., Bove, G., Gallo, V., Schlehofer, B., Tjonneland, A., Olsen, A., Overvad, K., Dahm, C. C., Teucher, B., Boeing, H., Steffen, A., Trichopoulou, A., Bamia, C., Kyrozis, A., Sacerdote, C., Agnoli, C., Palli, D., Tumino, R., Mattiello, A., ... Riboli, E. (2011). Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study. Cancer Prevention Research, 4(9), 1385-1392. https://doi.org/10.1158/1940-6207.CAPR-11-0014

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title = "Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study",

abstract = "Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the analysis for measures of body fat, height, and physical activity among 380,775 participants. All analyses were conducted using Cox proportional hazards model and controlling for age, sex, country, and education. A 71% increase in risk of meningioma was observed among men and women in the top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73, P-trend = 0.01). A positive association was also observed for BMI and meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI >= 30 compared with a BMI of 20-24.9, P-trend = 0.05). An association with height and meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10 cm increase). In contrast, no associations were observed for height and different measures of body fat and risk of glioma. Physical activity was not related to either type of brain tumors. Results from this study support an increase in risk of meningioma with higher body fatness among both men and women. No association was observed between anthropometric measures and risk of glioma. Cancer Prev Res; 4(9); 1385-92. (C) 2011 AACR.",

keywords = "BRAIN-TUMORS, CANCER, HEIGHT, WEIGHT, GROWTH, OVERWEIGHT, MORTALITY, VALIDITY, OBESITY, LIFE",

author = "Michaud, {Dominique S.} and Gerald Bove and Valentina Gallo and Brigitte Schlehofer and Anne Tjonneland and Anja Olsen and Kim Overvad and Dahm, {Christina C.} and Brigit Teucher and Heiner Boeing and Annika Steffen and Antonia Trichopoulou and Christina Bamia and Andreas Kyrozis and Carlotta Sacerdote and Claudia Agnoli and Domenico Palli and Rosario Tumino and Amalia Mattiello and Bueno-de-Mesquita, {H. Bas} and Peeters, {Petra H. M.} and May, {Anne M.} and Aurelio Barricarte and Maria-Dolores Chirlaque and Miren Dorronsoro and {Jose Sanchez}, Maria and Laudina Rodriguez and Duell, {Eric J.} and Goran Hallmans and Melin, {Beatrice S.} and Jonas Manjer and Signe Borgquist and Kay-Tee Khaw and Nick Wareham and Allen, {Naomi E.} and Travis, {Ruth C.} and Isabelle Romieu and Paolo Vineis and Elio Riboli",

note = "{\textcopyright}2011 AACR.",

year = "2011",

month = sep,

doi = "10.1158/1940-6207.CAPR-11-0014",

language = "English",

volume = "4",

pages = "1385--1392",

journal = "Cancer Prevention Research",

issn = "1940-6207",

publisher = "AMER ASSOC CANCER RESEARCH",

number = "9",

}

Michaud, DS, Bove, G, Gallo, V, Schlehofer, B, Tjonneland, A, Olsen, A, Overvad, K, Dahm, CC, Teucher, B, Boeing, H, Steffen, A, Trichopoulou, A, Bamia, C, Kyrozis, A, Sacerdote, C, Agnoli, C, Palli, D, Tumino, R, Mattiello, A, Bueno-de-Mesquita, HB, Peeters, PHM, May, AM, Barricarte, A, Chirlaque, M-D, Dorronsoro, M, Jose Sanchez, M, Rodriguez, L, Duell, EJ, Hallmans, G, Melin, BS, Manjer, J, Borgquist, S, Khaw, K-T, Wareham, N, Allen, NE, Travis, RC, Romieu, I, Vineis, P & Riboli, E 2011, 'Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study', Cancer Prevention Research, vol. 4, no. 9, pp. 1385-1392. https://doi.org/10.1158/1940-6207.CAPR-11-0014

TY - JOUR

T1 - Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study

AU - Michaud, Dominique S.

AU - Bove, Gerald

AU - Gallo, Valentina

AU - Schlehofer, Brigitte

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Overvad, Kim

AU - Dahm, Christina C.

AU - Teucher, Brigit

AU - Boeing, Heiner

AU - Steffen, Annika

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Kyrozis, Andreas

AU - Sacerdote, Carlotta

AU - Agnoli, Claudia

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Mattiello, Amalia

AU - Bueno-de-Mesquita, H. Bas

AU - Peeters, Petra H. M.

AU - May, Anne M.

AU - Barricarte, Aurelio

AU - Chirlaque, Maria-Dolores

AU - Dorronsoro, Miren

AU - Jose Sanchez, Maria

AU - Rodriguez, Laudina

AU - Duell, Eric J.

AU - Hallmans, Goran

AU - Melin, Beatrice S.

AU - Manjer, Jonas

AU - Borgquist, Signe

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Allen, Naomi E.

AU - Travis, Ruth C.

AU - Romieu, Isabelle

AU - Vineis, Paolo

AU - Riboli, Elio

PY - 2011/9

Y1 - 2011/9

N2 - Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the analysis for measures of body fat, height, and physical activity among 380,775 participants. All analyses were conducted using Cox proportional hazards model and controlling for age, sex, country, and education. A 71% increase in risk of meningioma was observed among men and women in the top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73, P-trend = 0.01). A positive association was also observed for BMI and meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI >= 30 compared with a BMI of 20-24.9, P-trend = 0.05). An association with height and meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10 cm increase). In contrast, no associations were observed for height and different measures of body fat and risk of glioma. Physical activity was not related to either type of brain tumors. Results from this study support an increase in risk of meningioma with higher body fatness among both men and women. No association was observed between anthropometric measures and risk of glioma. Cancer Prev Res; 4(9); 1385-92. (C) 2011 AACR.

AB - Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. Using data from a large European propective cohort, 203 incident cases of meningioma and 340 cases of glioma were included in the analysis for measures of body fat, height, and physical activity among 380,775 participants. All analyses were conducted using Cox proportional hazards model and controlling for age, sex, country, and education. A 71% increase in risk of meningioma was observed among men and women in the top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73, P-trend = 0.01). A positive association was also observed for BMI and meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI >= 30 compared with a BMI of 20-24.9, P-trend = 0.05). An association with height and meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10 cm increase). In contrast, no associations were observed for height and different measures of body fat and risk of glioma. Physical activity was not related to either type of brain tumors. Results from this study support an increase in risk of meningioma with higher body fatness among both men and women. No association was observed between anthropometric measures and risk of glioma. Cancer Prev Res; 4(9); 1385-92. (C) 2011 AACR.

KW - BRAIN-TUMORS

KW - CANCER

KW - HEIGHT

KW - WEIGHT

KW - GROWTH

KW - OVERWEIGHT

KW - MORTALITY

KW - VALIDITY

KW - OBESITY

KW - LIFE

U2 - 10.1158/1940-6207.CAPR-11-0014

DO - 10.1158/1940-6207.CAPR-11-0014

M3 - Article

C2 - 21685234

SN - 1940-6207

VL - 4

SP - 1385

EP - 1392

JO - Cancer Prevention Research

JF - Cancer Prevention Research

IS - 9

ER -

Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study

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Keywords

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