TY - JOUR
T1 - A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery
AU - Shahbazi, Mohammad Ali
AU - Shrestha, Neha
AU - Pierchala, Malgorzata Karolina
AU - Kadumudi, Firoz Babu
AU - Mehrali, Mehdi
AU - Hasany, Masoud
AU - Préat, Véronique
AU - Leeuwenburgh, Sander
AU - Dolatshahi-Pirouz, Alireza
N1 - Funding Information:
ADP would like to acknowledge the Danish Council for Independent Research (Technology and Production Sciences, 5054-00142B), Gigtforeningen (R139-A3864), the Villum Foundation (10103) and the VIDI research programme with project number R0004387, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). M.-A. S. acknowledges financial support from Iran's National Elites Foundation. N. S. would like to acknowledge funding from the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement number 751257.
Funding Information:
ADP would like to acknowledge the Danish Council for Independent Research (Technology and Production Sciences, 5054-00142B), Gigtforeningen (R139-A3864), the Villum Foundation (10103) and the VIDI research programme with project number R0004387, which is (partly) financed by the Netherlands Organisation for Scientific Research (NWO). M.-A. S. acknowledges financial support from Iran’s National Elites Foundation. N. S. would like to acknowledge funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement number 751257.
Publisher Copyright:
© The Royal Society of Chemistry 2020.
PY - 2020/5/21
Y1 - 2020/5/21
N2 - One of the long-standing challenges in materials science involves synthesizing biomaterials that recapitulate important features of native biological tissues. Even though, the number of available biomaterials at the moment are virtually limitless, few of them has unlocked all the secrets of the human body by mimicking the combinatorial-like material properties of our tissues and organs. Inspired by the human body, we have developed a polymeric gum, which combines stretchability, toughness, strength, flexibility, and self-healing. It also exhibits a high bioactivity that can target and eliminate bacterial infections fast and reliably. Notably, this material is moldable into almost any complex shape, and therefore suitable as a building block for wearables designed to conform directly with the curved and personalized anatomy of patients. It also exhibits excellent drug retention and release capacity, which altogether makes it suitable for applications in personalized wearable drug-delivery devices.
AB - One of the long-standing challenges in materials science involves synthesizing biomaterials that recapitulate important features of native biological tissues. Even though, the number of available biomaterials at the moment are virtually limitless, few of them has unlocked all the secrets of the human body by mimicking the combinatorial-like material properties of our tissues and organs. Inspired by the human body, we have developed a polymeric gum, which combines stretchability, toughness, strength, flexibility, and self-healing. It also exhibits a high bioactivity that can target and eliminate bacterial infections fast and reliably. Notably, this material is moldable into almost any complex shape, and therefore suitable as a building block for wearables designed to conform directly with the curved and personalized anatomy of patients. It also exhibits excellent drug retention and release capacity, which altogether makes it suitable for applications in personalized wearable drug-delivery devices.
U2 - 10.1039/c9tb02156f
DO - 10.1039/c9tb02156f
M3 - Article
C2 - 32363370
AN - SCOPUS:85084965314
SN - 2050-750X
VL - 8
SP - 4340
EP - 4356
JO - Journal of materials chemistry b
JF - Journal of materials chemistry b
IS - 19
ER -