A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Francesca L. Crowe; Timothy J. Key; Naomi E. Allen; Paul N. Appleby; Kim Overvad; Henning Gronbaek; Anne Tjonneland; Jytte Halkjaer; Laure Dossus; Heiner Boeing; Janine Kroeger; Antonia Trichopoulou; Dimosthenis Zylis; Dimitrios Trichopoulos; Marie-Christine Boutron-Ruault; Blandine de Lauzon-Guillain; Francoise Clavel-Chapelon; Domenico Palli; Franco Berrino; Salvatore Panico; Rosario Tumino; Carlotta Sacerdote; H. Bas Bueno-de-Mesquita; Carla H. van Gils; Petra H. M. Peeters; Inger T. Gram; Laudina Rodriguez; Paula Jakszyn; Esther Molina-Montes; Carmen Navarro; Aurelio Barricarte; Nerea Larranaga; Kay-Tee Khaw; Sheila Rodwell; Sabina Rinaldi; Nadia Slimani; Teresa Norat; Valentina Gallo; Elio Riboli; Rudolf Kaaks

doi:10.3109/03014460.2010.507221

A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Francesca L. Crowe^*, Timothy J. Key, Naomi E. Allen, Paul N. Appleby, Kim Overvad, Henning Gronbaek, Anne Tjonneland, Jytte Halkjaer, Laure Dossus, Heiner Boeing, Janine Kroeger, Antonia Trichopoulou, Dimosthenis Zylis, Dimitrios Trichopoulos, Marie-Christine Boutron-Ruault, Blandine de Lauzon-Guillain, Francoise Clavel-Chapelon, Domenico Palli, Franco Berrino, Salvatore PanicoRosario Tumino, Carlotta Sacerdote, H. Bas Bueno-de-Mesquita, Carla H. van Gils, Petra H. M. Peeters, Inger T. Gram, Laudina Rodriguez, Paula Jakszyn, Esther Molina-Montes, Carmen Navarro, Aurelio Barricarte, Nerea Larranaga, Kay-Tee Khaw, Sheila Rodwell, Sabina Rinaldi, Nadia Slimani, Teresa Norat, Valentina Gallo, Elio Riboli, Rudolf Kaaks

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

67 Citations (Scopus)

Abstract

Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk.

Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3.

Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC).

Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all <0.001).

Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.

Original language	English
Pages (from-to)	194-202
Number of pages	9
Journal	Annals of human biology
Volume	38
Issue number	2
DOIs	https://doi.org/10.3109/03014460.2010.507221
Publication status	Published - Mar-2011
Externally published	Yes

Keywords

Body height
body mass index
insulin-like growth factor I
insulin-like growth factor binding proteins
obesity
GROWTH-FACTOR-I
BODY-MASS INDEX
FACTOR BINDING-PROTEIN-3 CONCENTRATIONS
BINDING-PROTEIN
FACTOR (IGF)-I
C-PEPTIDE
INSULIN
RISK
WOMEN
HORMONE

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A cross-sectional analysis of the associations between adult height, BMI and serum concentrations
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Crowe, F. L., Key, T. J., Allen, N. E., Appleby, P. N., Overvad, K., Gronbaek, H., Tjonneland, A., Halkjaer, J., Dossus, L., Boeing, H., Kroeger, J., Trichopoulou, A., Zylis, D., Trichopoulos, D., Boutron-Ruault, M.-C., de Lauzon-Guillain, B., Clavel-Chapelon, F., Palli, D., Berrino, F., ... Kaaks, R. (2011). A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). Annals of human biology, 38(2), 194-202. https://doi.org/10.3109/03014460.2010.507221

@article{a58eb30485fa4d6f86716e618154f01b,

title = "A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)",

abstract = "Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk.Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3.Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC).Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all <0.001).Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.",

keywords = "Body height, body mass index, insulin-like growth factor I, insulin-like growth factor binding proteins, obesity, GROWTH-FACTOR-I, BODY-MASS INDEX, FACTOR BINDING-PROTEIN-3 CONCENTRATIONS, BINDING-PROTEIN, FACTOR (IGF)-I, C-PEPTIDE, INSULIN, RISK, WOMEN, HORMONE",

author = "Crowe, {Francesca L.} and Key, {Timothy J.} and Allen, {Naomi E.} and Appleby, {Paul N.} and Kim Overvad and Henning Gronbaek and Anne Tjonneland and Jytte Halkjaer and Laure Dossus and Heiner Boeing and Janine Kroeger and Antonia Trichopoulou and Dimosthenis Zylis and Dimitrios Trichopoulos and Marie-Christine Boutron-Ruault and {de Lauzon-Guillain}, Blandine and Francoise Clavel-Chapelon and Domenico Palli and Franco Berrino and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and Bueno-de-Mesquita, {H. Bas} and {van Gils}, {Carla H.} and Peeters, {Petra H. M.} and Gram, {Inger T.} and Laudina Rodriguez and Paula Jakszyn and Esther Molina-Montes and Carmen Navarro and Aurelio Barricarte and Nerea Larranaga and Kay-Tee Khaw and Sheila Rodwell and Sabina Rinaldi and Nadia Slimani and Teresa Norat and Valentina Gallo and Elio Riboli and Rudolf Kaaks",

year = "2011",

month = mar,

doi = "10.3109/03014460.2010.507221",

language = "English",

volume = "38",

pages = "194--202",

journal = "Annals of human biology",

issn = "0301-4460",

publisher = "Informa Healthcare",

number = "2",

}

Crowe, FL, Key, TJ, Allen, NE, Appleby, PN, Overvad, K, Gronbaek, H, Tjonneland, A, Halkjaer, J, Dossus, L, Boeing, H, Kroeger, J, Trichopoulou, A, Zylis, D, Trichopoulos, D, Boutron-Ruault, M-C, de Lauzon-Guillain, B, Clavel-Chapelon, F, Palli, D, Berrino, F, Panico, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, HB, van Gils, CH, Peeters, PHM, Gram, IT, Rodriguez, L, Jakszyn, P, Molina-Montes, E, Navarro, C, Barricarte, A, Larranaga, N, Khaw, K-T, Rodwell, S, Rinaldi, S, Slimani, N, Norat, T, Gallo, V, Riboli, E & Kaaks, R 2011, 'A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)', Annals of human biology, vol. 38, no. 2, pp. 194-202. https://doi.org/10.3109/03014460.2010.507221

A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Crowe, Francesca L.; Key, Timothy J.; Allen, Naomi E. et al.
In: Annals of human biology, Vol. 38, No. 2, 03.2011, p. 194-202.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Crowe, Francesca L.

AU - Key, Timothy J.

AU - Allen, Naomi E.

AU - Appleby, Paul N.

AU - Overvad, Kim

AU - Gronbaek, Henning

AU - Tjonneland, Anne

AU - Halkjaer, Jytte

AU - Dossus, Laure

AU - Boeing, Heiner

AU - Kroeger, Janine

AU - Trichopoulou, Antonia

AU - Zylis, Dimosthenis

AU - Trichopoulos, Dimitrios

AU - Boutron-Ruault, Marie-Christine

AU - de Lauzon-Guillain, Blandine

AU - Clavel-Chapelon, Francoise

AU - Palli, Domenico

AU - Berrino, Franco

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Bueno-de-Mesquita, H. Bas

AU - van Gils, Carla H.

AU - Peeters, Petra H. M.

AU - Gram, Inger T.

AU - Rodriguez, Laudina

AU - Jakszyn, Paula

AU - Molina-Montes, Esther

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Larranaga, Nerea

AU - Khaw, Kay-Tee

AU - Rodwell, Sheila

AU - Rinaldi, Sabina

AU - Slimani, Nadia

AU - Norat, Teresa

AU - Gallo, Valentina

AU - Riboli, Elio

AU - Kaaks, Rudolf

PY - 2011/3

Y1 - 2011/3

N2 - Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk.Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3.Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC).Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all <0.001).Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.

AB - Background: Height and BMI are risk factors for several types of cancer and may be related to circulating concentrations of insulin-like growth factor-I (IGF-I), a peptide associated with increased cancer risk.Aim: To assess the associations between height, BMI and serum concentrations of IGF-I and IGF binding protein (IGFBP)-1, -2 and -3.Subjects and methods: This cross-sectional analysis included 1142 men and 3589 women aged 32-77 years from the multi-centre study, the European Prospective Investigation of Cancer and Nutrition (EPIC).Results: In men, there was a positive association between height and IGF-I; each 10 cm increment in height was associated with an increase in IGF-I concentrations of 4.3% (95% confidence interval (CI): 1.3-7.5%, p for trend = 0.005), but this association was not statistically significant for women (0.9%, 95% CI: -0.7 to 2.6%, p for trend = 0.264). In both men and women, the association between IGF-I and BMI was non-linear and those with a BMI of 26-27 kg/m(2) had the highest IGF-I concentration. BMI was strongly inversely related to concentrations of IGFBP-1 and IGFBP-2 in men and in women (p for trend for all <0.001).Conclusion: Height and BMI are associated with IGF-I and its binding proteins, which may be mechanisms through which body size contributes to increased risk of several cancers.

KW - Body height

KW - body mass index

KW - insulin-like growth factor I

KW - insulin-like growth factor binding proteins

KW - obesity

KW - GROWTH-FACTOR-I

KW - BODY-MASS INDEX

KW - FACTOR BINDING-PROTEIN-3 CONCENTRATIONS

KW - BINDING-PROTEIN

KW - FACTOR (IGF)-I

KW - C-PEPTIDE

KW - INSULIN

KW - RISK

KW - WOMEN

KW - HORMONE

U2 - 10.3109/03014460.2010.507221

DO - 10.3109/03014460.2010.507221

M3 - Article

C2 - 20731527

SN - 0301-4460

VL - 38

SP - 194

EP - 202

JO - Annals of human biology

JF - Annals of human biology

IS - 2

ER -

A cross-sectional analysis of the associations between adult height, BMI and serum concentrations of IGF-I and IGFBP-1-2 and-3 in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Abstract

Keywords

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