3D Pressure Field in Lipid Membranes and Membrane-Protein Complexes

O. H. Samuli Ollila; H. Jelger Risselada; Martti Louhivuori; Erik Lindahl; Ilpo Vattulainen; Siewert J. Marrink

doi:10.1103/physrevlett.102.078101

3D Pressure Field in Lipid Membranes and Membrane-Protein Complexes

O. H. Samuli Ollila^*, H. Jelger Risselada, Martti Louhivuori, Erik Lindahl, Ilpo Vattulainen, Siewert J. Marrink

^*Corresponding author for this work

Molecular Dynamics

Research output: Contribution to journal › Article › Academic › peer-review

183 Citations (Scopus)

12 Downloads (Pure)

Abstract

We calculate full 3D pressure fields for inhomogeneous nanoscale systems using molecular dynamics simulation data. The fields represent systems with increasing level of complexity, ranging from semivesicles and vesicles to membranes characterized by coexistence of two phases, including also a protein-membrane complex. We show that the 3D pressure field is distinctly different for curved and planar bilayers, the pressure field depends strongly on the phase of the membrane, and that an integral protein modulates the tension and elastic properties of the membrane.

Original language	English
Article number	078101
Number of pages	4
Journal	Physical Review Letters
Volume	102
Issue number	7-20
DOIs	https://doi.org/10.1103/physrevlett.102.078101
Publication status	Published - 20-Feb-2009

Keywords

COARSE-GRAINED MODEL
LATERAL PRESSURE
FORCE-FIELD
SIMULATIONS
PROFILES
BILAYERS
TENSION
MSCL
PHOSPHATIDYLCHOLINE
MODULATION

Access to Document

10.1103/physrevlett.102.078101

Handle.net

Persistent link

Embargoed Document

3D Pressure Field in Lipid Membranes and Membrane-Protein Complexes
Final publisher's version, 533 KB
Request copy

Cite this

@article{c4f6e856b11d4b0296b7ff8a6d9ab705,

title = "3D Pressure Field in Lipid Membranes and Membrane-Protein Complexes",

abstract = "We calculate full 3D pressure fields for inhomogeneous nanoscale systems using molecular dynamics simulation data. The fields represent systems with increasing level of complexity, ranging from semivesicles and vesicles to membranes characterized by coexistence of two phases, including also a protein-membrane complex. We show that the 3D pressure field is distinctly different for curved and planar bilayers, the pressure field depends strongly on the phase of the membrane, and that an integral protein modulates the tension and elastic properties of the membrane.",

keywords = "COARSE-GRAINED MODEL, LATERAL PRESSURE, FORCE-FIELD, SIMULATIONS, PROFILES, BILAYERS, TENSION, MSCL, PHOSPHATIDYLCHOLINE, MODULATION",

author = "Ollila, {O. H. Samuli} and Risselada, {H. Jelger} and Martti Louhivuori and Erik Lindahl and Ilpo Vattulainen and Marrink, {Siewert J.}",

year = "2009",

month = feb,

day = "20",

doi = "10.1103/physrevlett.102.078101",

language = "English",

volume = "102",

journal = "Physical Review Letters",

issn = "0031-9007",

publisher = "AMER PHYSICAL SOC",

number = "7-20",

}

TY - JOUR

T1 - 3D Pressure Field in Lipid Membranes and Membrane-Protein Complexes

AU - Ollila, O. H. Samuli

AU - Risselada, H. Jelger

AU - Louhivuori, Martti

AU - Lindahl, Erik

AU - Vattulainen, Ilpo

AU - Marrink, Siewert J.

PY - 2009/2/20

Y1 - 2009/2/20

N2 - We calculate full 3D pressure fields for inhomogeneous nanoscale systems using molecular dynamics simulation data. The fields represent systems with increasing level of complexity, ranging from semivesicles and vesicles to membranes characterized by coexistence of two phases, including also a protein-membrane complex. We show that the 3D pressure field is distinctly different for curved and planar bilayers, the pressure field depends strongly on the phase of the membrane, and that an integral protein modulates the tension and elastic properties of the membrane.

AB - We calculate full 3D pressure fields for inhomogeneous nanoscale systems using molecular dynamics simulation data. The fields represent systems with increasing level of complexity, ranging from semivesicles and vesicles to membranes characterized by coexistence of two phases, including also a protein-membrane complex. We show that the 3D pressure field is distinctly different for curved and planar bilayers, the pressure field depends strongly on the phase of the membrane, and that an integral protein modulates the tension and elastic properties of the membrane.

KW - COARSE-GRAINED MODEL

KW - LATERAL PRESSURE

KW - FORCE-FIELD

KW - SIMULATIONS

KW - PROFILES

KW - BILAYERS

KW - TENSION

KW - MSCL

KW - PHOSPHATIDYLCHOLINE

KW - MODULATION

U2 - 10.1103/physrevlett.102.078101

DO - 10.1103/physrevlett.102.078101

M3 - Article

SN - 0031-9007

VL - 102

JO - Physical Review Letters

JF - Physical Review Letters

IS - 7-20

M1 - 078101

ER -

3D Pressure Field in Lipid Membranes and Membrane-Protein Complexes

Abstract

Keywords

Access to Document

Handle.net

Embargoed Document

Fingerprint

Cite this